Temozolomide - Just a Radiosensitizer?
DNA repair
MGMT
apoptosis
glioblastoma
radiotherapy
temozolomide
treatment protocols
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
04
2022
accepted:
05
05
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
6
7
2022
Statut:
epublish
Résumé
Radiation concomitant with the DNA methylating drug temozolomide (TMZ) is the gold standard in the treatment of glioblastoma. In this adjuvant setting, TMZ is regarded to be a radiation sensitizer. However, similar to ionising radiation, TMZ induces DNA double-strand breaks and is itself a potent trigger of apoptosis, cellular senescence and autophagy, suggesting that radiation and TMZ act independently. Although cell culture experiments yielded heterogeneous results, some data indicate that the cytotoxic effect of radiation was only enhanced when TMZ was given before radiation treatment. Based on the molecular mechanism of action of TMZ, the importance of specific TMZ and radiation-induced DNA lesions, their repair as well as their interactions, possible scenarios for an additive or synergistic effect of TMZ and radiation are discussed, and suggestions for an optimal timing of radio-chemical treatments are proposed.
Identifiants
pubmed: 35785203
doi: 10.3389/fonc.2022.912821
pmc: PMC9246413
doi:
Types de publication
Journal Article
Langues
eng
Pagination
912821Informations de copyright
Copyright © 2022 Kaina, Beltzig and Strik.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Anticancer Res. 2013 Aug;33(8):3487-94
pubmed: 23898124
Oncogene. 2007 Jan 11;26(2):186-97
pubmed: 16819506
N Engl J Med. 2005 Mar 10;352(10):997-1003
pubmed: 15758010
Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1246-53
pubmed: 17967314
Neurology. 2004 Jun 8;62(11):2113-5
pubmed: 15184628
Mol Cancer Ther. 2013 Nov;12(11):2529-40
pubmed: 23960094
Oncogene. 2004 Jan 15;23(2):359-67
pubmed: 14724564
Int J Cancer. 2010 Nov 1;127(9):2106-18
pubmed: 20131314
Mol Cell Biol. 2003 Aug;23(16):5706-15
pubmed: 12897142
J Neurooncol. 2017 Sep;134(3):479-485
pubmed: 28271281
Cell Cycle. 2010 Jan 1;9(1):168-78
pubmed: 20016283
Cancer Lett. 2013 May 28;332(2):237-48
pubmed: 22261329
Carcinogenesis. 1991 Oct;12(10):1857-67
pubmed: 1657427
Cancer Res. 2019 Jan 1;79(1):99-113
pubmed: 30361254
Curr Med Chem Anticancer Agents. 2002 Nov;2(6):727-42
pubmed: 12678723
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 May;49(5):771-81
pubmed: 3516900
Int J Radiat Oncol Biol Phys. 2000 Jun 1;47(3):779-84
pubmed: 10837964
DNA Repair (Amst). 2009 Jan 1;8(1):72-86
pubmed: 18840549
Front Oncol. 2013 May 10;3:113
pubmed: 23675572
Lancet Oncol. 2009 May;10(5):459-66
pubmed: 19269895
Clin Cancer Res. 2006 Aug 1;12(15):4738-46
pubmed: 16899625
Cancer Gene Ther. 2002 Sep;9(9):737-46
pubmed: 12189523
Toxicology. 2003 Nov 15;193(1-2):3-34
pubmed: 14599765
Oncol Rep. 2006 Nov;16(5):1117-21
pubmed: 17016602
Mol Cancer Ther. 2021 Oct;20(10):1789-1799
pubmed: 34253592
DNA Repair (Amst). 2007 Aug 1;6(8):1079-99
pubmed: 17485253
Mutat Res. 1995 Jan;336(1):9-17
pubmed: 7528899
Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7491-5
pubmed: 1323840
Mutat Res Rev Mutat Res. 2019 Apr - Jun;780:15-28
pubmed: 31395346
Mutat Res. 1990 Jul;231(1):11-30
pubmed: 2195323
Curr Neurol Neurosci Rep. 2012 Jun;12(3):286-93
pubmed: 22437507
Clin Cancer Res. 2008 Feb 1;14(3):931-8
pubmed: 18245557
Mol Cancer Res. 2019 May;17(5):1129-1141
pubmed: 30796178
Cancer Res. 2000 Oct 15;60(20):5815-24
pubmed: 11059778
PLoS One. 2013;8(1):e55665
pubmed: 23383259
J Neurochem. 2018 Jan;144(2):139-151
pubmed: 29164620
Int J Mol Sci. 2019 Mar 28;20(7):
pubmed: 30925722
Lancet. 2019 Feb 16;393(10172):678-688
pubmed: 30782343
DNA Repair (Amst). 2019 Jun;78:128-141
pubmed: 31039537
Biomedicines. 2019 Nov 11;7(4):
pubmed: 31717973
Mol Cancer Ther. 2010 May;9(5):1208-18
pubmed: 20457618
Cancers (Basel). 2021 Dec 14;13(24):
pubmed: 34944906