Sustained release of sulforaphane by bioactive extracellular vesicles for neuroprotective effect on chick model.
autism
chick embryo
extracellular vesicles
hPC12 cells
release mechanism
sulforaphane
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
06
06
2022
received:
11
01
2022
accepted:
13
06
2022
pubmed:
6
7
2022
medline:
19
10
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
Novel studies have shown neurological treatment possibilities with extracellular vesicles (EVs) as natural particles with a special composition that are produced by different cell types. Their stability, natural structure, composition, and bioavailability make them good candidates as drug vehicles. Here, EVs were isolated from amniotic fluid (AF) through differential centrifugation, and characterized for size (<200 nm), structure, and composition, their effectiveness on the human PC12 cell line, and brain of chick embryos exposed to sodium valproate (animal autistic model). Sulforaphane (SFN) was employed as a bioactive compound and then encapsulated into Evs using three methods including passive (incubation), active (sonication), and active-passive (sonication-incubation). Further, the loading and in vitro releases of SFN fitted the Korsmeyer-Peppas (R
Substances chimiques
Delayed-Action Preparations
0
Interleukin-6
0
Isothiocyanates
0
NF-E2-Related Factor 2
0
Neuroprotective Agents
0
Sulfoxides
0
Valproic Acid
614OI1Z5WI
sulforaphane
GA49J4310U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2636-2648Informations de copyright
© 2022 Wiley Periodicals LLC.
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