Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in inflammatory bowel diseases.
IBD
SIgA
glycosylation
immunity
microbiota
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
08 08 2022
08 08 2022
Historique:
revised:
15
06
2022
received:
05
11
2021
accepted:
15
06
2022
pubmed:
6
7
2022
medline:
10
8
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse-transcytosis, the apical-to-basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microbiota requires broad affinity IgA and glycan-glycan interaction. Here, we asked whether IgA1 and IgA2-microbiota interactions might be involved in dysbiosis induction during inflammatory bowel diseases. Using stool HPLC-purified IgA, we show that reverse-transcytosis is abrogated in ulcerative colitis (UC) while it is extended to IgA1 in Crohn's disease (CD). 16S RNA sequencing of IgA-bound microbiota in CD and UC showed distinct IgA1- and IgA2-associated microbiota; the IgA1
Identifiants
pubmed: 35785473
doi: 10.15252/emmm.202115386
pmc: PMC9358401
doi:
Substances chimiques
Immunoglobulin A
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15386Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
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