Maternal free fatty acid concentration during pregnancy is associated with newborn hypothalamic microstructure in humans.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
23
02
2022
received:
07
10
2021
accepted:
25
03
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
8
7
2022
Statut:
ppublish
Résumé
This study tested the hypothesis, in a prospective cohort study design, that maternal saturated free fatty acid (sFFA) concentration during pregnancy is prospectively associated with offspring (newborn) hypothalamic (HTH) microstructure and to explore the functional relevance of this association with respect to early-childhood body fat percentage (BF%). In N = 94 healthy newborns (born mean 39.3 [SD 1.5] weeks gestation), diffusion-weighted magnetic resonance imaging was performed shortly after birth (25.3 [12.5] postnatal days), and a subgroup (n = 37) underwent a dual-energy x-ray absorptiometry scan in early childhood (4.7 [SD 0.7] years). Maternal sFFA concentration during pregnancy was quantified in fasting blood samples via liquid chromatography-mass spectrometry. Infant HTH microstructural integrity was characterized using mean diffusivity (MD). Multiple linear regression was used to test the association between maternal sFFA and HTH MD, accounting for newborn sex, age at scan, mean white matter MD, and image quality. Multiple linear regression models also tested the association between HTH MD and early-childhood BF%, accounting for breastfeeding status. Maternal sFFA during pregnancy accounted for 8.3% of the variation in newborn HTH MD (β-std = 0.25; p = 0.006). Furthermore, newborn HTH MD prospectively accounted for 15% of the variation in early-childhood BF% (β-std = 0.32; p = 0.019). These findings suggest that maternal overnutrition during pregnancy may influence the development of the fetal hypothalamus, which, in turn, may have clinical relevance for childhood obesity risk.
Identifiants
pubmed: 35785481
doi: 10.1002/oby.23452
pmc: PMC9541037
doi:
Substances chimiques
Fatty Acids, Nonesterified
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1462-1471Subventions
Organisme : NIH HHS
ID : UG3 OD023349
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK118578
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105538
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH091351
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD100593
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001414
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023349
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD060628
Pays : United States
Organisme : NICHD NIH HHS
ID : R00 HD096109
Pays : United States
Informations de copyright
© 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).
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