[Expression of galectin-13 in allergic diseases involving airway, skin and mucous membranes].

To detect the expression of galectin-13 in allergic diseases and provide a new way for the diagnosis and treatment of allergic diseases. A retrospective analysis method was used to screen 216 patients with allergic diseases with house dust mites or aspergillus as allergens who visited the Department of Allergy and Department of Respiratory of Tongji Hospital attached Tongji Medical College, Huazhong University of Science and Technology from March 2018 to May 2021. These allergic diseases included allergic asthma, allergic bronchopulmonary aspergillosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, allergic urticaria. 25 subjects without underlying diseases were selected as healthy controls. The galectin-13 content in serum in each group were detected, and the Pearson correlation was used to determine the correlation between the galectin-13 content in serum in each group and blood eosinophil count, blood specific IgE, the score scale of allergic disease. The expression of Galectin-13 was increased in allergic asthma group (71.44±39.44) pg/ml, allergic bronchopulmonary aspergillosis group (100.10±47.62) pg/ml, allergic rhinitis group (54.11±24.81) pg/ml and dermatitis group (44.12±19.51) pg/ml. The expression of galectin-13 was not significantly increased in allergic urticaria group (32.75±10.29) pg/ml and the allergic conjunctivitis group (30.55±9.87) pg/ml. The galectin-13 content in serum, was positively correlated with blood eosinophil count( 探讨半乳糖凝集素-13（galectin-13，Gal-13）在过敏性疾病中的表达情况，为过敏性疾病的诊疗提供新途径。采用回顾性分析方法，筛查2018年3月至2021年5月于华中科技大学同济医学院附属同济医院过敏反应科和呼吸内科就诊的，以屋尘螨或曲霉为过敏原的过敏性疾病患者216例。这些过敏性疾病包括过敏性哮喘、变应性支气管肺曲霉病、过敏性鼻炎、变应性结膜炎、特应性皮炎、变应性荨麻疹。选取25例无基础疾病受试者作为健康对照。检测各组疾病血浆Gal-13含量，并采用Pearson相关判断各组疾病血浆Gal-13含量与血嗜酸性粒细胞计数、血特异性IgE、过敏性疾病相关评分量表等的相关性。结果显示，Gal-13在过敏性哮喘组（71.44±39.44）pg/ml、变应性支气管肺曲霉病组（100.10±47.62）pg/ml、过敏性鼻炎组（54.11±24.81）pg/ml、特应性皮炎组（44.12±19.51）pg/ml中表达均显著升高，在变应性荨麻疹组（32.75±10.29）pg/ml和变应性结膜炎组（30.55±9.87）pg/ml无明显升高。过敏性哮喘患者血浆Gal-13含量与血嗜酸性粒细胞计数（