Hyperoxia evokes pericyte-mediated capillary constriction.


Journal

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566

Informations de publication

Date de publication:
Nov 2022
Historique:
pubmed: 6 7 2022
medline: 19 10 2022
entrez: 5 7 2022
Statut: ppublish

Résumé

Oxygen supplementation is regularly prescribed to patients to treat or prevent hypoxia. However, excess oxygenation can lead to reduced cerebral blood flow (CBF) in healthy subjects and worsen the neurological outcome of critically ill patients. Most studies on the vascular effects of hyperoxia focus on arteries but there is no research on the effects on cerebral capillary pericytes, which are major regulators of CBF. Here, we used bright-field imaging of cerebral capillaries and modeling of CBF to show that hyperoxia (95% superfused O

Identifiants

pubmed: 35786054
doi: 10.1177/0271678X221111598
pmc: PMC9580167
doi:

Substances chimiques

Endothelin-1 0
Reactive Oxygen Species 0
Oxygen S88TT14065
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2032-2047

Subventions

Organisme : Wellcome Trust
ID : 740427
Pays : United Kingdom

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Auteurs

Chanawee Hirunpattarasilp (C)

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, UK.
Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.

Anna Barkaway (A)

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, UK.
Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.

Harvey Davis (H)

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, UK.
Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.

Thomas Pfeiffer (T)

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, UK.

Huma Sethi (H)

Division of Neurosurgery, UCL Queen Square Institute of Neurology, Queen Square, London, UK.

David Attwell (D)

Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, UK.

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Classifications MeSH