The complex lipid, SPPCT-800, reduces lung damage, improves pulmonary function and decreases pro-inflammatory cytokines in the murine LPS-induced acute respiratory distress syndrome (ARDS) model.
Acute respiratory distress syndrome
bronchoalveolar lavage fluid
inflammatory cytokines
lung index
lung injury
Journal
Pharmaceutical biology
ISSN: 1744-5116
Titre abrégé: Pharm Biol
Pays: England
ID NLM: 9812552
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
7
7
2022
Statut:
ppublish
Résumé
Acute respiratory distress syndrome (ARDS) is a highly fatal, inflammatory condition of lungs with multiple causes. There is no adequate treatment. Using the murine LPS-induced ARDS model, we investigate SPPCT-800 (a complex lipid) as treatment for ARDS. C57B16/N mice received 50 μg of At 48 and 72 h, SpO SPPCT-800 was effective in reducing manifestations of ARDS. SPPCT-800 should be further investigated as therapy for ARDS, especially in longer duration or higher cumulative dose studies.
Identifiants
pubmed: 35786152
doi: 10.1080/13880209.2022.2087689
pmc: PMC9255205
doi:
Substances chimiques
Cytokines
0
Lipopolysaccharides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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