Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.


Journal

Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673

Informations de publication

Date de publication:
04 07 2022
Historique:
received: 10 03 2022
accepted: 18 06 2022
entrez: 5 7 2022
pubmed: 6 7 2022
medline: 7 7 2022
Statut: epublish

Résumé

Cerebrospinal fluid (CSF) biomarkers play an important role in diagnosing Alzheimer's disease (AD) which is characterized by amyloid-β (Aβ) amyloidosis. Here, we used two App knock-in mouse models, App

Identifiants

pubmed: 35787306
doi: 10.1186/s40478-022-01398-5
pii: 10.1186/s40478-022-01398-5
pmc: PMC9254429
doi:

Substances chimiques

Amyloid beta-Peptides 0
Decorin 0
Proteome 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

96

Informations de copyright

© 2022. The Author(s).

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Auteurs

Richeng Jiang (R)

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden. richeng.jiang@ki.se.
Department of Otolaryngology Head and Neck Surgery, The First Hospital of Jilin University, Changchun, 130021, China. richeng.jiang@ki.se.

Una Smailovic (U)

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, 141 52, Huddinge, Sweden.
Department of Clinical Neurophysiology, Karolinska University Hospital, Stockholm, Sweden.

Hazal Haytural (H)

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.

Betty M Tijms (BM)

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.

Hao Li (H)

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.
Department of Neurosurgery, The Second Affiliated Hospital of Shaanxi Chinese Medicine University, Xianyang, 712000, Shaanxi, China.

Robert Mihai Haret (RM)

Division of Physiology and Neuroscience, Carol Davila University of Medicine and Pharmacy, 050474, Bucharest, Romania.

Ganna Shevchenko (G)

Department of Chemistry - BMC, Analytical Chemistry and Neurochemistry, Uppsala University, 752 37, Uppsala, Sweden.

Gefei Chen (G)

Department of Biosciences and Nutrition, Karolinska Institutet, 141 52, Huddinge, Sweden.

Axel Abelein (A)

Department of Biosciences and Nutrition, Karolinska Institutet, 141 52, Huddinge, Sweden.

Johan Gobom (J)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 413 45, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 413 45, Mölndal, Sweden.

Susanne Frykman (S)

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.

Misaki Sekiguchi (M)

Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.

Ryo Fujioka (R)

Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.

Naoto Watamura (N)

Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.

Hiroki Sasaguri (H)

Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.

Sofie Nyström (S)

IFM-Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.

Per Hammarström (P)

IFM-Department of Physics, Chemistry and Biology, Linköping University, 581 83, Linköping, Sweden.

Takaomi C Saido (TC)

Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.

Vesna Jelic (V)

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Clinical Geriatrics, Karolinska Institutet, 141 52, Huddinge, Sweden.

Stina Syvänen (S)

Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, 751 85, Uppsala, Sweden.

Henrik Zetterberg (H)

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 413 45, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 413 45, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, WC1N 3BG, UK.
UK Dementia Research Institute at UCL, London, WC1E 6BT, UK.
Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.

Bengt Winblad (B)

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.
Theme Inflammation and Aging, Karolinska University Hospital, 141 52, Huddinge, Sweden.

Jonas Bergquist (J)

Department of Chemistry - BMC, Analytical Chemistry and Neurochemistry, Uppsala University, 752 37, Uppsala, Sweden.

Pieter Jelle Visser (PJ)

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden.
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1007 MB, Amsterdam, The Netherlands.
Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, 6211 LK, Maastricht, The Netherlands.

Per Nilsson (P)

Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, 171 64, Stockholm, Sweden. Per.et.Nilsson@ki.se.

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