Neutralization capacity of antibodies elicited through homologous or heterologous infection or vaccination against SARS-CoV-2 VOCs.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 07 2022
04 07 2022
Historique:
received:
21
01
2022
accepted:
22
06
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
7
7
2022
Statut:
epublish
Résumé
Emerging SARS-CoV-2 variants raise questions about escape from previous immunity. As the population immunity to SARS-CoV-2 has become more complex due to prior infections with different variants, vaccinations or the combination of both, understanding the antigenic relationship between variants is needed. Here, we have assessed neutralizing capacity of 120 blood specimens from convalescent individuals infected with ancestral SARS-CoV-2, Alpha, Beta, Gamma or Delta, double vaccinated individuals and patients after breakthrough infections with Delta or Omicron-BA.1. Neutralization against seven authentic SARS-CoV-2 isolates (B.1, Alpha, Beta, Gamma, Delta, Zeta and Omicron-BA.1) determined by plaque-reduction neutralization assay allowed us to map the antigenic relationship of SARS-CoV-2 variants. Highest neutralization titers were observed against the homologous variant. Antigenic cartography identified Zeta and Omicron-BA.1 as separate antigenic clusters. Substantial immune escape in vaccinated individuals was detected for Omicron-BA.1 but not Zeta. Combined infection/vaccination derived immunity results in less Omicron-BA.1 immune escape. Last, breakthrough infections with Omicron-BA.1 lead to broadly neutralizing sera.
Identifiants
pubmed: 35787633
doi: 10.1038/s41467-022-31556-1
pii: 10.1038/s41467-022-31556-1
pmc: PMC9253337
doi:
Substances chimiques
Antibodies
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3840Informations de copyright
© 2022. The Author(s).
Références
Nat Commun. 2021 Aug 17;12(1):5061
pubmed: 34404775
Cell Host Microbe. 2021 Apr 14;29(4):516-521.e3
pubmed: 33798491
Science. 2022 Jan 14;375(6577):183-192
pubmed: 34855510
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Cell. 2020 Sep 3;182(5):1295-1310.e20
pubmed: 32841599
Nat Med. 2021 Jul;27(7):1205-1211
pubmed: 34002089
PLoS Pathog. 2021 Dec 2;17(12):e1010022
pubmed: 34855916
Sci Rep. 2021 Jul 1;11(1):13705
pubmed: 34210996
N Engl J Med. 2020 Dec 17;383(25):2439-2450
pubmed: 33053279
Euro Surveill. 2021 Jun;26(24):
pubmed: 34142653
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Science. 2020 Mar 13;367(6483):1260-1263
pubmed: 32075877
Elife. 2020 Oct 28;9:
pubmed: 33112236
Nat Microbiol. 2022 Apr;7(4):524-529
pubmed: 35365787
Euro Surveill. 2022 Jan;27(4):
pubmed: 35086609
Nature. 2021 Apr;592(7854):438-443
pubmed: 33690265
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
J Clin Virol. 2020 Sep;130:104572
pubmed: 32769024
J Clin Microbiol. 2020 Oct 21;58(11):
pubmed: 32826322
Cell. 2021 Apr 29;184(9):2384-2393.e12
pubmed: 33794143
N Engl J Med. 2020 Nov 12;383(20):1920-1931
pubmed: 32663912
Clin Microbiol Infect. 2020 Oct;26(10):1386-1394
pubmed: 32603801
Nature. 2022 Mar;603(7902):679-686
pubmed: 35042229
Sci Rep. 2021 Nov 8;11(1):21601
pubmed: 34750399
Science. 2004 Jul 16;305(5682):371-6
pubmed: 15218094
Nature. 2022 Feb;602(7898):654-656
pubmed: 35016196
NPJ Vaccines. 2021 Nov 29;6(1):142
pubmed: 34845231
Elife. 2021 Jul 29;10:
pubmed: 34323691
N Engl J Med. 2021 Dec 16;385(25):2397-2399
pubmed: 34731554
Cell Host Microbe. 2021 Mar 10;29(3):463-476.e6
pubmed: 33592168
N Engl J Med. 2021 Jun 17;384(24):2352-2354
pubmed: 33826819
Science. 2021 Mar 12;371(6534):1152-1153
pubmed: 33514629
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):
pubmed: 34417349
mSphere. 2021 Mar 10;6(2):
pubmed: 33692194
Science. 2021 Apr 9;372(6538):
pubmed: 33658326
N Engl J Med. 2022 Feb 3;386(5):492-494
pubmed: 34965337
N Engl J Med. 2022 Mar 17;386(11):1088-1091
pubmed: 35081298
Nature. 2021 Apr;592(7852):122-127
pubmed: 33636719
PLoS Med. 2021 Dec 6;18(12):e1003868
pubmed: 34871308
Lancet. 2022 Jan 15;399(10321):234-236
pubmed: 34942101
J Infect. 2021 Oct;83(4):467-472
pubmed: 34320390
N Engl J Med. 2022 Feb 17;386(7):698-700
pubmed: 35021005
Cell Host Microbe. 2021 May 12;29(5):747-751.e4
pubmed: 33887205
Science. 2021 May 21;372(6544):815-821
pubmed: 33853970
J Virol. 2021 Mar 1;:
pubmed: 33649194
JAMA. 2021 Jul 21;:
pubmed: 34287620
Cell. 2022 Feb 3;185(3):457-466.e4
pubmed: 34995482
bioRxiv. 2021 Jan 11;:
pubmed: 33442690
Zool Res. 2021 Nov 18;42(6):789-791
pubmed: 34704423
Nat Commun. 2020 Sep 17;11(1):4704
pubmed: 32943637
Vaccine. 2021 Jul 22;39(32):4423-4428
pubmed: 34210573
Nature. 2021 Nov;599(7883):114-119
pubmed: 34488225
Nature. 2022 Feb;602(7896):307-313
pubmed: 34937050
Nature. 2021 May;593(7857):136-141
pubmed: 33706364
Genomics. 2021 Jul;113(4):2158-2170
pubmed: 34004284