The association between body fat distribution and bone mineral density: evidence from the US population.
Android fat
BMD
Fat distribution
Gynoid fat
NHANES
Journal
BMC endocrine disorders
ISSN: 1472-6823
Titre abrégé: BMC Endocr Disord
Pays: England
ID NLM: 101088676
Informations de publication
Date de publication:
04 Jul 2022
04 Jul 2022
Historique:
received:
04
05
2022
accepted:
27
06
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
7
7
2022
Statut:
epublish
Résumé
To investigate the association between different body fat distribution and different sites of BMD in male and female populations. Use the National Health and Nutrition Examination Survey (NHANES) datasets to select participants. The weighted linear regression model investigated the difference in body fat and Bone Mineral Density (BMD) in different gender. Multivariate adjusted smoothing curve-fitting and multiple linear regression models were used to explore whether an association existed between body fat distribution and BMD. Last, a subgroup analysis was performed according to age and gender group. Overall, 2881 participants were included in this study. Compared to males, female participants had lower BMD (P < 0.05) and higher Gynoid fat mass (P < 0.00001), while there was no difference between Android fat mass (P = 0.91). Android fat mass was positively associated with Total femur BMD (Males, β = 0.044, 95% CI = 0.037, 0.051, P < 0.00001; Females, β = 0.044, 95% CI = 0.039, 0.049, P < 0.00001), Femoral neck BMD (Males, β = 0.034, 95% CI = 0.027, 0.041, P < 0.00001; Females, β = 0.032, 95% CI = 0.027, 0.037, P < 0.00001), and Total spine BMD (Males, β = 0.036, 95% CI = 0.029, 0.044, P < 0.00001; Females, β = 0.025, 95% CI = 0.019, 0.031, P < 0.00001). The Gynoid fat mass, subgroup analysis of age and ethnicity reached similar results. Body fat in different regions was positively associated with BMD in different sites, and this association persisted in subgroup analyses across age and race in different gender.
Identifiants
pubmed: 35787696
doi: 10.1186/s12902-022-01087-3
pii: 10.1186/s12902-022-01087-3
pmc: PMC9254427
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
170Informations de copyright
© 2022. The Author(s).
Références
J Endocrinol. 2002 Nov;175(2):405-15
pubmed: 12429038
J Am Coll Cardiol. 2013 Sep 3;62(10):921-5
pubmed: 23850922
Clin Endocrinol (Oxf). 2015 Mar;82(3):377-87
pubmed: 24974911
J Clin Endocrinol Metab. 2002 Mar;87(3):1327-36
pubmed: 11889205
Int J Mol Sci. 2019 Jul 27;20(15):
pubmed: 31357654
Best Pract Res Clin Endocrinol Metab. 2007 Sep;21(3):415-30
pubmed: 17875489
Int J Obes Relat Metab Disord. 1994 Jun;18 Suppl 1:S1-7
pubmed: 8087159
Diabetes Metab Syndr Obes. 2011;4:273-82
pubmed: 21792326
Nat Commun. 2019 Jan 21;10(1):339
pubmed: 30664634
Circ Cardiovasc Imaging. 2016 Jun;9(6):
pubmed: 27307550
Nat Commun. 2019 Jun 3;10(1):2408
pubmed: 31160598
Curr Osteoporos Rep. 2020 Feb;18(1):1-12
pubmed: 31897866
PLoS One. 2013 May 20;8(5):e63339
pubmed: 23700417
J Bone Miner Res. 1996 May;11(5):626-37
pubmed: 9157777
J Exp Med. 1997 Aug 18;186(4):489-95
pubmed: 9254647
J Am Coll Cardiol. 2015 May 19;65(19):2150-1
pubmed: 25975481
Lancet Diabetes Endocrinol. 2019 Mar;7(3):231-240
pubmed: 30704950
Endocrine. 2014 Dec;47(3):862-8
pubmed: 24705911
Obes Rev. 2009 Mar;10(2):154-67
pubmed: 19021872
Cell Death Differ. 2016 Jul;23(7):1128-39
pubmed: 26868907
Front Endocrinol (Lausanne). 2022 Jan 25;13:829867
pubmed: 35145487
Sports Med. 1992 Apr;13(4):245-69
pubmed: 1615253
Sci Rep. 2016 Apr 26;6:24935
pubmed: 27112305
Obstet Gynecol. 2000 May;95(5):722-5
pubmed: 10775737
Climacteric. 2020 Apr;23(2):206-210
pubmed: 31736370
J Bone Miner Res. 2012 Oct;27(10):2208-16
pubmed: 22623101
Obes Surg. 2021 Mar;31(3):1147-1157
pubmed: 33145717
Endocrinology. 1989 Feb;124(2):701-6
pubmed: 2536316
Bone. 2014 Jun;63:132-40
pubmed: 24603002
J Clin Densitom. 2013 Jul-Sep;16(3):353-359
pubmed: 23910719
Gerontology. 2018;64(3):229-236
pubmed: 29212073
Int J Obes (Lond). 2010 Dec;34(12):1752-8
pubmed: 20498655
Cell Mol Life Sci. 2013 Jul;70(13):2331-49
pubmed: 23178849
J Clin Densitom. 2013 Apr-Jun;16(2):168-77
pubmed: 22575590
ESC Heart Fail. 2020 Jun;7(3):1101-1108
pubmed: 32220062
Diabetologia. 2008 Dec;51(12):2233-41
pubmed: 18839131
Arch Intern Med. 2000 Jul 24;160(14):2117-28
pubmed: 10904454
Front Nutr. 2021 Oct 15;8:763677
pubmed: 34722617
Obesity (Silver Spring). 2016 Nov;24(11):2414-2421
pubmed: 27667735
N Engl J Med. 2008 Nov 13;359(20):2105-20
pubmed: 19005195
Eur Rev Med Pharmacol Sci. 2021 Dec;25(1 Suppl):14-22
pubmed: 34890030
Int J Epidemiol. 2020 Jun 1;49(3):810-823
pubmed: 32016289
Osteoporos Int. 2015 Apr;26(4):1381-6
pubmed: 25572048
J Bone Miner Metab. 2009;27(3):341-6
pubmed: 19229474
Ann Intern Med. 2016 Apr 19;164(8):532-41
pubmed: 26954388
Osteoporos Int. 2011 Jan;22(1):113-9
pubmed: 20306018
J Bone Miner Res. 1995 Jul;10(7):1015-24
pubmed: 7484276
Nutrition. 2017 Jan;33:14-19
pubmed: 27908545
Calcif Tissue Int. 2010 Feb;86(2):116-25
pubmed: 19957167