Calculating the precision of slope-intercept glomerular filtration rate measurements.
Journal
Nuclear medicine communications
ISSN: 1473-5628
Titre abrégé: Nucl Med Commun
Pays: England
ID NLM: 8201017
Informations de publication
Date de publication:
01 Aug 2022
01 Aug 2022
Historique:
pubmed:
6
7
2022
medline:
19
7
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
Glomerular filtration rate (GFR) can be measured by observing the clearance of a suitable tracer from blood plasma after an intravenous injection. Slope-intercept GFR is an estimate of GFR calculated from an exponential fit to multiple blood sample measurements. The precision of the result depends on the uncertainties on all the measured quantities, but the most important factor is the error on the slope and intercept of the fit. However, these two errors are not independent as an increase in slope tends to produce an increase in intercept as well. This study derives the appropriate equations for calculating the precision of the result and shows that, if this dependence is not taken into account, the uncertainty in GFR can be significantly overestimated. The advantage of using Chi-square as a quality control measure is also introduced.
Identifiants
pubmed: 35788099
doi: 10.1097/MNM.0000000000001593
pii: 00006231-202208000-00015
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
959-966Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Références
Fleming JS, Zivanovic MA, Blake GM, Burniston M, Cosgriff PS. Guidelines for the measurement of glomerular filtration rate using plasma sampling. Nucl Med Commun. 2004; 25:759–769
Burniston M. Clinical guidelines for the measurement of glomerular filtration rate (GFR) using plasma sampling. British Nuclear Medicine Society, 2018. http://www.bnms.org.uk .