Advances in studying human gametogenesis and embryonic development in China†.
embryo
epigenetic regulatory networks
gametes
human
transcriptome
Journal
Biology of reproduction
ISSN: 1529-7268
Titre abrégé: Biol Reprod
Pays: United States
ID NLM: 0207224
Informations de publication
Date de publication:
25 07 2022
25 07 2022
Historique:
received:
21
01
2022
revised:
21
05
2022
accepted:
20
06
2022
pubmed:
6
7
2022
medline:
28
7
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
Reproductive medicine in China has developed rapidly since 1988 due to support from the government and scientific exploration. However, the success rate of assisted reproduction technology is around 30-40% and many unknown "black boxes" in gametogenesis and embryo development are still present. With the development of single-cell and low-input sequencing technologies, the network of transcriptome and epigenetic regulation (DNA methylation, chromatin accessibility, and histone modifications) during the development of human primordial germ cells, gametes, and embryos has been investigated in depth. Furthermore, preimplantation genetic testing has also rapidly developed. In this review, we summarize and analyze China's outstanding progress in these fields.
Identifiants
pubmed: 35788258
pii: 6628544
doi: 10.1093/biolre/ioac134
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12-26Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.