Structural variants shape driver combinations and outcomes in pediatric high-grade glioma.

Brain Neoplasms / genetics Cell Cycle Proteins / genetics Child Glioma / genetics Histones / genetics Humans Mutation Proto-Oncogene Proteins / genetics

Journal

Nature cancer
ISSN: 2662-1347
Titre abrégé: Nat Cancer
Pays: England
ID NLM: 101761119

Informations de publication

Date de publication:
08 2022
Historique:
received: 30 10 2021
accepted: 23 05 2022
pubmed: 6 7 2022
medline: 27 8 2022
entrez: 5 7 2022
Statut: ppublish

Résumé

We analyzed the contributions of structural variants (SVs) to gliomagenesis across 179 pediatric high-grade gliomas (pHGGs). The most recurrent SVs targeted MYC isoforms and receptor tyrosine kinases (RTKs), including an SV amplifying a MYC enhancer in 12% of diffuse midline gliomas (DMG), indicating an underappreciated role for MYC in pHGG. SV signature analysis revealed that tumors with simple signatures were TP53 wild type (TP53

Identifiants

DOI: 10.1038/s43018-022-00403-z PMID: 35788723 PMC: PMC10365847
pubmed: 35788723
doi: 10.1038/s43018-022-00403-z
pii: 10.1038/s43018-022-00403-z
pmc: PMC10365847
mid: NIHMS1907773
doi:

Substances chimiques

Cell Cycle Proteins 0
Histones 0
MDM4 protein, human 0
Proto-Oncogene Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

994-1011

Subventions

Organisme : NCI NIH HHS
ID : R01 CA188228
Pays : United States
Organisme : Cancer Research UK
ID : 13982
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA219943
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA215489
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA255245
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Frank P B Dubois (FPB)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-7654-6208

Ofer Shapira (O)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Noah F Greenwald (NF)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-7836-4379

Travis Zack (T)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jeremiah Wala (J)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jessica W Tsai (JW)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
ORCID: 0000-0003-0540-4330

Alexander Crane (A)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Audrey Baguette (A)

Quantitative Life Sciences, McGill University, Montreal, QC, Canada.
ORCID: 0000-0001-8011-2341

Djihad Hadjadj (D)

Department of Human Genetics, McGill University, Montreal, QC, Canada.

Ashot S Harutyunyan (AS)

Department of Human Genetics, McGill University, Montreal, QC, Canada.
ORCID: 0000-0002-9050-9315

Kiran H Kumar (KH)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Mirjam Blattner-Johnson (M)

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Division of Pediatric Glioma Research, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Jayne Vogelzang (J)

Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Cecilia Sousa (C)

Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Kyung Shin Kang (KS)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Claire Sinai (C)

Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Dayle K Wang (DK)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
ORCID: 0000-0002-2185-1782

Prasidda Khadka (P)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Kathleen Lewis (K)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Lan Nguyen (L)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Hayley Malkin (H)

Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.

Patricia Ho (P)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-4622-8188

Ryan O'Rourke (R)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Shu Zhang (S)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Rose Gold (R)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Davy Deng (D)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jonathan Serrano (J)

New York University Medical Center, New York, NY, USA.

Matija Snuderl (M)

New York University Medical Center, New York, NY, USA.

Chris Jones (C)

Division of Cancer Therapeutics and Department of Molecular Pathology, Institute of Cancer Research 15 Cotswold Road, Sutton, London, UK.

Karen D Wright (KD)

Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.

Susan N Chi (SN)

Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.

Jacques Grill (J)

Department of Pediatric and Adolescent Oncology and INSERM Unit 981, Gustave Roussy Institute and University of Paris Saclay, Villejuif, France.

Claudia L Kleinman (CL)

Department of Human Genetics, McGill University, Montreal, QC, Canada.
Lady Davis Research Institute, Jewish General Hospital, Montreal, QC, Canada.
ORCID: 0000-0002-5158-7126

Liliana C Goumnerova (LC)

Department of Neurosurgery, Boston Children's Hospital; Dana Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
LCG: Tromboprotea, MWK: Day One Biopharmaceuticals, San Francisco, CA, USA.
ORCID: 0000-0002-2662-719X

Nada Jabado (N)

Department of Human Genetics, McGill University, Montreal, QC, Canada.
Division of Experimental Medicine, Department of Medicine and Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
ORCID: 0000-0003-2485-3692

David T W Jones (DTW)

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Division of Pediatric Glioma Research, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-2036-5141

Mark W Kieran (MW)

Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA.
LCG: Tromboprotea, MWK: Day One Biopharmaceuticals, San Francisco, CA, USA.

Keith L Ligon (KL)

Broad Institute of MIT and Harvard, Cambridge, MA, USA. keith_ligon@dfci.harvard.edu.
Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. keith_ligon@dfci.harvard.edu.
Department of Pathology, Brigham & Women's Hospital and Boston Children's Hospital, Boston, USA. keith_ligon@dfci.harvard.edu.
Center for Patient Derived Models, Dana-Farber Cancer Institute, Boston, MA, USA. keith_ligon@dfci.harvard.edu.
ORCID: 0000-0002-7733-600X

Rameen Beroukhim (R)

Department of Cancer Biology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. rameen_beroukhim@dfci.harvard.edu.
Broad Institute of MIT and Harvard, Cambridge, MA, USA. rameen_beroukhim@dfci.harvard.edu.
Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. rameen_beroukhim@dfci.harvard.edu.
ORCID: 0000-0001-6303-3609

Pratiti Bandopadhayay (P)

Broad Institute of MIT and Harvard, Cambridge, MA, USA. pratiti_bandopadhayay@dfci.harvard.edu.
Department of Pediatrics, Harvard Medical School, Boston, MA, USA. pratiti_bandopadhayay@dfci.harvard.edu.
Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. pratiti_bandopadhayay@dfci.harvard.edu.
ORCID: 0000-0002-4175-4760

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Structural variants shape driver combinations...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Structural variants shape driver combinations...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Structural variants shape driver combinations...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Structural variants shape driver combinations...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Structural variants shape driver combinations...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural variants shape driver combinations...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Structural variants shape driver combinations...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Structural variants shape driver combinations...