A symptomatic intercalated duct lesion of the parotid gland: a case report with immunohistochemical and genetic analyses.
Adenomatous ductal proliferation/hyperplasia
CTNNB1 gene
Intercalated duct lesion. parotid gland
β-Catenin
Journal
Medical molecular morphology
ISSN: 1860-1499
Titre abrégé: Med Mol Morphol
Pays: Japan
ID NLM: 101239023
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
07
05
2022
accepted:
16
06
2022
pubmed:
6
7
2022
medline:
29
10
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
Intercalated duct lesions (IDLs) are usually asymptomatic. We report a case of IDL, in which a palpable mass formed. The patient was a 45-year-old Japanese male, who noticed a mass in the left parotid region. The nodular lesion was well-circumscribed, but did not have a fibrous capsule or exhibit infiltrative growth. It contained a small cystic space and consisted of basaloid cells arranged in a cribriform pattern and inner ductal cells. It had some solid areas of nest-like proliferation displaying mild cellular atypia. Immunohistochemically, the luminal cells were positive for cytokeratin (CK)7 and epithelial membrane antigen, and the abluminal cells were positive for CK5/6, p63, and DOG1. S-100 protein-positive stromal cells were also seen. The lesion's cells were all positive for SOX10, and the nuclei of some basaloid cells were positive for β-catenin. The Ki-67 labeling index was 3.8%. The ductal cells contained diastase-digestion-resistant, Periodic acid Schiff-positive zymogen granules. Genetically, the lesion harbored a missense mutation in the CTNNB1 gene. We diagnosed the lesion as an IDL. As IDLs are usually small non-neoplastic lesions, symptomatic cases are rare. Based on its common immunohistochemical and genetic features, IDL may be a precursor of basal cell adenoma/adenocarcinoma, such as intercalated duct adenoma.
Identifiants
pubmed: 35789287
doi: 10.1007/s00795-022-00328-7
pii: 10.1007/s00795-022-00328-7
doi:
Substances chimiques
beta Catenin
0
Mucin-1
0
Ki-67 Antigen
0
Periodic Acid
10450-60-9
S100 Proteins
0
Keratins
68238-35-7
Amylases
EC 3.2.1.-
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
329-336Subventions
Organisme : the Medical Research Support Project of Shizuoka Prefectural Hospital Organization
ID : 2021
Informations de copyright
© 2022. The Author(s) under exclusive licence to The Japanese Society for Clinical Molecular Morphology.
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