Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine.

Adipocytes, Brown / drug effects Adipose Tissue, Brown / drug effects Adipose Tissue, White / drug effects Animals Energy Metabolism / drug effects Equilibrative Nucleoside Transporter 1 / antagonists & inhibitors Humans Inosine / metabolism Mice Obesity / genetics Thermogenesis / genetics Uncoupling Protein 1 / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2022
Historique:
received: 11 11 2021
accepted: 29 06 2022
pubmed: 6 7 2022
medline: 11 9 2022
entrez: 5 7 2022
Statut: ppublish

Résumé

Brown adipose tissue (BAT) dissipates energy

Identifiants

DOI: 10.1038/s41586-022-05041-0 PMID: 35790189 PMC: PMC9452294
pubmed: 35790189
doi: 10.1038/s41586-022-05041-0
pii: 10.1038/s41586-022-05041-0
pmc: PMC9452294
doi:

Substances chimiques

Equilibrative Nucleoside Transporter 1 0
SLC29A1 protein, human 0
SLC29A1 protein, mouse 0
UCP1 protein, human 0
Uncoupling Protein 1 0
Inosine 5A614L51CT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

361-368

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK122796
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133900
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL154720
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM135118
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

© 2022. The Author(s).

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Auteurs

Birte Niemann (B)

Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany. Bini@uni-bonn.de.
ORCID: 0000-0002-0128-803X

Saskia Haufs-Brusberg (S)

Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.

Laura Puetz (L)

Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.

Martin Feickert (M)

Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.
ORCID: 0000-0002-1911-7810

Michelle Y Jaeckstein (MY)

Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Anne Hoffmann (A)

Helmholtz Institute for Metabolic Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.

Jelena Zurkovic (J)

Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.

Markus Heine (M)

Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Eva-Maria Trautmann (EM)

Institute for Diabetes and Obesity, Helmholtz Center Munich, Neuherberg, Germany.

Christa E Müller (CE)

Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, Bonn, Germany.
PharmaCenter Bonn, University of Bonn, Bonn, Germany.
ORCID: 0000-0002-0013-6624

Anke Tönjes (A)

Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.

Christian Schlein (C)

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Azin Jafari (A)

Clinic and Polyclinic for General, Visceral, Thoracic and Vascular Surgery, University Hospital, University of Bonn, Bonn, Germany.

Holger K Eltzschig (HK)

Department of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas, USA.
ORCID: 0000-0002-5676-6473

Thorsten Gnad (T)

Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany.
ORCID: 0000-0003-0169-3067

Matthias Blüher (M)

Helmholtz Institute for Metabolic Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany.
Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
ORCID: 0000-0003-0208-2065

Natalie Krahmer (N)

Institute for Diabetes and Obesity, Helmholtz Center Munich, Neuherberg, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.

Peter Kovacs (P)

Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.
ORCID: 0000-0002-0290-5423

Joerg Heeren (J)

Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Alexander Pfeifer (A)

Institute of Pharmacology and Toxicology, University Hospital, University of Bonn, Bonn, Germany. Alexander.Pfeifer@uni-bonn.de.
PharmaCenter Bonn, University of Bonn, Bonn, Germany. Alexander.Pfeifer@uni-bonn.de.
ORCID: 0000-0001-8805-6831

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Adipocytes bruns › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux brun › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux blanc › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Eucaryotes › Animaux › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs équilibrants de nucléosides › Transporteur équilibrant de nucléosides de type 1 › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Inosine › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Phénomènes biologiques › Adaptation biologique › Adaptation physiologique › Régulation de la température corporelle › Thermogenèse › Apoptotic brown adipocytes enhance energy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › Protéines de découplage mitochondrial › Protéine-1 de découplage › Apoptotic brown adipocytes enhance energy...