Predictors of post-TAVI conduction abnormalities in patients with bicuspid aortic valves.

OBJECTIVES

This study evaluates predictors of conduction abnormalities (CA) following transcatheter aortic valve implantation (TAVI) in patients with bicuspid aortic valves (BAV).

BACKGROUND

TAVI is associated with CA that commonly necessitate a permanent pacemaker. Predictors of CA are well established among patients with tricuspid aortic valves but not in those with BAV.

METHODS

This is a single-centre, retrospective, observational study of patients with BAV treated with TAVI. Pre-TAVI ECG and CT scans and procedural characteristics were evaluated in 58 patients with BAV. CA were defined as a composite of high-degree atrioventricular block, new left bundle branch block with a QRS >150 ms or PR >240 ms and right bundle branch block with new PR prolongation or change in axis. Predictors of CA were identified using regression analysis and optimum cut-off values determined using area under the receiver operating characteristic curve analysis.

RESULTS

CA occurred in 35% of patients. Bioprosthesis implantation depth, the difference between membranous septum (MS) length and implantation depth (

CONCLUSIONS

In BAV patients undergoing TAVI, short

Informations de copyright

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/coi_disclosure.pdf and declare: no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work. FP has received research support from Siemens Healthineers. AWCC has received Research grant from Boston Scientific and Abbott. AM is employed by Abbott Medical UK. MM has received grants and personal fees from Edwards Lifesciences and personal fees from Abbott Vascular. KPP is funded by a British Heart Foundation clinical research training fellowship grant (FS/19/48/34523) and has an unrestricted research grant from Edwards Lifesciences.