[Inhibition of Sonic Hedgehog signaling inhibits fibrous scar formation and adversely affects functional outcome after ischemic brain injury in rats].
Shh signaling
cerebral ischemia
fibro-blasts
myofibroblasts
Journal
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
ISSN: 1673-4254
Titre abrégé: Nan Fang Yi Ke Da Xue Xue Bao
Pays: China
ID NLM: 101266132
Informations de publication
Date de publication:
20 Jun 2022
20 Jun 2022
Historique:
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
8
7
2022
Statut:
ppublish
Résumé
To investigate the effects of inhibiting Sonic Hedgehog (Shh) signaling on fibrous scar formation and functional outcome after ischemic brain injury. Adult SD rats were randomized into sham-operated group, middle cerebral artery occlusion (MCAO) and reperfusion (I/R) group, I/R with intraventricular empty adenoviral vector (rAd-NC) injection group, and I/R with adenovirus-mediated Shh knockdown (rAd-ShShh) group. After the treatments, the neurological deficits of the rats were assessed, and the protein and mRNA expressions of fibronectin (Fn), Cerebral I/R injury significantly increased the protein and mRNA expressions of Shh, Inhibition of Shh signaling may inhibit fibrous scar formation and functional recovery in rats after ischemic brain injury.
Identifiants
pubmed: 35790434
doi: 10.12122/j.issn.1673-4254.2022.06.07
pmc: PMC9257362
doi:
Substances chimiques
Hedgehog Proteins
0
RNA, Messenger
0
Transforming Growth Factor beta1
0
Types de publication
Journal Article
Langues
chi
Sous-ensembles de citation
IM
Pagination
840-848Références
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