Diagnostic value of oral "beefy red" patch combined with fingertip blood mean corpuscular volume in vitamin B12 deficiency.
Diagnostic test
Diagnostic treatment
Mean corpuscular volume
Vitamin B12 deficiency
“Beefy red” patch
Journal
BMC oral health
ISSN: 1472-6831
Titre abrégé: BMC Oral Health
Pays: England
ID NLM: 101088684
Informations de publication
Date de publication:
05 07 2022
05 07 2022
Historique:
received:
04
04
2022
accepted:
24
06
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
8
7
2022
Statut:
epublish
Résumé
To investigate the diagnostic value of accessible fingertip mean corpuscular volume (MCV) combined with a visible "beefy red" patch in the diagnosis of vitamin B12 (VB12) deficiency in local clinics and hospitals without in-house clinical laboratories, especially in remote areas. The medical history data of patients complaining of oral mucosal pain at the Stomatological Hospital of Southern Medical University were reviewed. All included patients underwent fingertip blood routine examination, specific serological test (serum VB12, folic acid, iron, and ferritin), and detailed oral clinical examinations. According to the results of the serum VB12 test patients were divided into case and control groups. In diagnostic test, the diagnostic value of the "beefy red" patch and elevated MCV in VB12 deficiency was evaluated by the receiver operator characteristic curve. There were more female patients than male patients in the case group (serum VB12 level < 148 pmol/L, n = 81) and control group (serum VB12 level ≥ 148 pmol/L, n = 60), mostly middle-aged and elderly patients. There were no statistical differences in gender and age between the two groups. In the case group, the number of individuals with stomach disease was 13, the number of individuals with "beefy red" patch was 78, the number of individuals with oral ulcer was 29, the number of individuals with "MCV > 100fL" and "folic acid < 15.9 nmol/L" were respectively 68 and 5. All were more than that in control group (P < 0.05). The diagnostic test, "beefy red patch" has high sensitivity (0.963) but low specificity(0.883), "MCV > 100 fL" has high specificity (0.933) but low specificity (0.815), and "MCV > 100 fL combined with beefy red patch" has maximal specificity (0.950), and area under the curve (0.949). Visible oral "beefy red" patch combined with accessible fingertip blood MCV could improve the rate of diagnosis in VB12 deficiency, especially in the elderly in local clinics and hospitals without in-house clinical laboratories in China, which is conducive to early disease detection and treatment.
Identifiants
pubmed: 35790943
doi: 10.1186/s12903-022-02309-9
pii: 10.1186/s12903-022-02309-9
pmc: PMC9258077
doi:
Substances chimiques
Ferritins
9007-73-2
Folic Acid
935E97BOY8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
273Informations de copyright
© 2022. The Author(s).
Références
Ther Clin Risk Manag. 2018 Aug 07;14:1391-1397
pubmed: 30122939
Cutan Ocul Toxicol. 2014 Mar;33(1):70-3
pubmed: 24303868
Public Health Nutr. 2010 Jan;13(1):25-31
pubmed: 19519972
J Pak Med Assoc. 2012 Nov;62(11):1223-9
pubmed: 23866416
Lancet Neurol. 2006 Nov;5(11):949-60
pubmed: 17052662
Oral Surg Oral Med Oral Pathol. 1981 Jul;52(1):38-42
pubmed: 6944676
J Biomed Sci. 2018 Aug 29;25(1):65
pubmed: 30157866
Public Health Nutr. 2015 Apr;18(5):836-43
pubmed: 24969611
Clin Lab Haematol. 1997 Mar;19(1):27-31
pubmed: 9146944
J Clin Lab Anal. 2020 Nov;34(11):e23441
pubmed: 33156552
Front Mol Biosci. 2016 Jun 27;3:27
pubmed: 27446930
J Oral Pathol Med. 1995 Nov;24(10):468-70
pubmed: 8600284
Nutr Clin Pract. 2021 Oct;36(5):1041-1048
pubmed: 33126294
J Oral Pathol Med. 2012 Jul;41(6):500-4
pubmed: 22188475
Br J Haematol. 2014 Aug;166(4):496-513
pubmed: 24942828
Pathology. 2011 Aug;43(5):472-81
pubmed: 21716160
Ann Dermatol Venereol. 2003 Feb;130(2 Pt 1):191-4
pubmed: 12671582
J Formos Med Assoc. 2016 Dec;115(12):1061-1068
pubmed: 27839675
BMC Oral Health. 2020 Sep 10;20(1):252
pubmed: 32912209
Age Ageing. 2007 Mar;36(2):177-83
pubmed: 17189285
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec;98(6):679-85
pubmed: 15583540
Am J Clin Nutr. 2009 Feb;89(2):693S-6S
pubmed: 19116323
Ann Clin Biochem. 2012 Mar;49(Pt 2):184-9
pubmed: 22302152
N Engl J Med. 2013 Jan 10;368(2):149-60
pubmed: 23301732
QJM. 2009 Jan;102(1):17-28
pubmed: 18990719
Natl Med J India. 2012 Nov-Dec;25(6):336-8
pubmed: 23998863
Nutr Clin Pract. 2013 Dec;28(6):710-21
pubmed: 24163321
Indian J Hematol Blood Transfus. 2013 Mar;29(1):26-30
pubmed: 24426329
Am Fam Physician. 2017 Sep 15;96(6):384-389
pubmed: 28925645
J Oral Pathol Med. 2015 Apr;44(4):300-5
pubmed: 25048341
J Dent Sci. 2020 Mar;15(1):34-41
pubmed: 32256998
J Clin Pathol. 2017 Feb;70(2):168-173
pubmed: 27169753
BMJ. 2014 Sep 04;349:g5226
pubmed: 25189324