Longitudinal associations of DNA methylation and sleep in children: a meta-analysis.
Actigraphy
Child
Epigenomics
Longitudinal studies
Meta-analysis
Methylation
Sleep
Journal
Clinical epigenetics
ISSN: 1868-7083
Titre abrégé: Clin Epigenetics
Pays: Germany
ID NLM: 101516977
Informations de publication
Date de publication:
05 07 2022
05 07 2022
Historique:
received:
25
02
2022
accepted:
04
06
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
8
7
2022
Statut:
epublish
Résumé
Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children. We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4-13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration. We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × 10 DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available.
Sections du résumé
BACKGROUND
Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at birth or in school age is associated with parent-reported and actigraphy-estimated sleep outcomes in children.
METHODS
We meta-analysed epigenome-wide association study results. DNA methylation was measured from cord blood at birth in 11 cohorts and from peripheral blood in children (4-13 years) in 8 cohorts. Outcomes included parent-reported sleep duration, sleep initiation and fragmentation problems, and actigraphy-estimated sleep duration, sleep onset latency and wake-after-sleep-onset duration.
RESULTS
We found no associations between DNA methylation at birth and parent-reported sleep duration (n = 3658), initiation problems (n = 2504), or fragmentation (n = 1681) (p values above cut-off 4.0 × 10
CONCLUSION
DNA methylation, at birth or in childhood, was not associated with parent-reported sleep. Associations observed with objectively measured sleep outcomes could be studied further if additional data sets become available.
Identifiants
pubmed: 35790973
doi: 10.1186/s13148-022-01298-4
pii: 10.1186/s13148-022-01298-4
pmc: PMC9258202
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
83Subventions
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023286
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD068437
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS047537
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111108
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR013945
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/I025263/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 217065/Z/19/Z
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : N01ES75558
Pays : United States
Organisme : Medical Research Council
ID : MR/S009310/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBI025751/1
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : Z01 ES049019
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Twin Res Hum Genet. 2015 Dec;18(6):662-9
pubmed: 26678051
Epigenetics. 2020 Sep;15(9):988-997
pubmed: 32202197
Sleep Med. 2012 Apr;13(4):385-9
pubmed: 22326832
PLoS One. 2012;7(7):e41361
pubmed: 22848472
Int J Epidemiol. 2018 Feb 1;47(1):22-23u
pubmed: 29025028
Nat Genet. 2019 Mar;51(3):394-403
pubmed: 30804565
Epigenetics. 2018;13(6):655-664
pubmed: 30044683
Sleep. 2018 Apr 1;41(4):
pubmed: 29590464
Bioinformatics. 2016 Jan 15;32(2):286-8
pubmed: 26424855
Wellcome Open Res. 2020 Dec 7;5:283
pubmed: 33969230
Nat Commun. 2019 Jan 29;10(1):343
pubmed: 30696823
Epigenetics. 2015;10(11):1024-32
pubmed: 26457534
Genet Epidemiol. 2018 Feb;42(1):20-33
pubmed: 29034560
Nat Commun. 2019 Mar 7;10(1):1100
pubmed: 30846698
Mol Psychiatry. 2021 Jun;26(6):1832-1845
pubmed: 33414500
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Nat Genet. 2017 Feb;49(2):274-281
pubmed: 27992416
Am J Phys Anthropol. 2019 May;169(1):3-11
pubmed: 30771258
Brief Bioinform. 2019 Nov 27;20(6):2224-2235
pubmed: 30239597
Wellcome Open Res. 2022 Feb 4;7:41
pubmed: 35592546
Epigenetics Chromatin. 2015 Jan 27;8:6
pubmed: 25972926
J Clin Sleep Med. 2018 Jul 15;14(7):1209-1230
pubmed: 29991438
Environ Health Perspect. 2017 Apr;125(4):511-526
pubmed: 28362264
Sci Rep. 2019 Feb 4;9(1):1193
pubmed: 30718923
Int J Epidemiol. 2019 Oct 1;48(5):1536-1544
pubmed: 30879037
Sleep. 2019 Sep 6;42(9):
pubmed: 31181146
J Child Psychol Psychiatry. 2020 Oct;61(10):1061-1069
pubmed: 32361995
J Child Psychol Psychiatry. 2012 Jul;53(7):806-14
pubmed: 22309313
Genome Med. 2020 Mar 2;12(1):25
pubmed: 32114984
Front Neural Circuits. 2018 Feb 27;12:14
pubmed: 29535611
Curr Neurol Neurosci Rep. 2014 Mar;14(3):432
pubmed: 24477387
Sleep. 2017 Jun 1;40(6):
pubmed: 28431118
Genome Biol. 2016 Oct 7;17(1):207
pubmed: 27717397
J Child Psychol Psychiatry. 2018 Apr;59(4):303-322
pubmed: 28736860
Nat Commun. 2019 Apr 23;10(1):1893
pubmed: 31015461
Epigenetics. 2016 May 3;11(5):354-62
pubmed: 27019159
Nat Commun. 2019 Aug 13;10(1):3503
pubmed: 31409809
Sleep Med Rev. 2021 Jun;57:101425
pubmed: 33601324
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
Bioinformatics. 2018 Dec 1;34(23):3983-3989
pubmed: 29931280
Nat Commun. 2016 Mar 09;7:10889
pubmed: 26955885
J Child Psychol Psychiatry. 2016 Mar;57(3):296-317
pubmed: 26412255
Sleep. 2009 Aug;32(8):1086-92
pubmed: 19725260
BMC Bioinformatics. 2010 May 28;11:288
pubmed: 20509871
Sci Rep. 2021 Jun 4;11(1):11834
pubmed: 34088929
Genom Data. 2016 May 26;9:22-4
pubmed: 27330998
Sleep Med. 2019 Apr;56:201-210
pubmed: 30819657
Am J Hum Genet. 2016 Apr 7;98(4):680-96
pubmed: 27040690
Bioinformatics. 2021 May 5;37(5):711-713
pubmed: 32805005
Arch Pediatr Adolesc Med. 2010 May;164(5):452-6
pubmed: 20439796
Epigenetics. 2013 Feb;8(2):203-9
pubmed: 23314698
EMBO Rep. 2021 Apr 7;22(4):e52196
pubmed: 33719206
Hum Mol Genet. 2021 Mar 25;30(1):119-134
pubmed: 33450751
Vascul Pharmacol. 2018 Feb;101:38-47
pubmed: 29174013
Sleep Med. 2015 Apr;16(4):496-502
pubmed: 25701537
Sleep Med Rev. 2020 Aug;52:101303
pubmed: 32320935