Longitudinal Analysis of SARS-CoV-2 Vaccine Breakthrough Infections Reveals Limited Infectious Virus Shedding and Restricted Tissue Distribution.
SARS-CoV-2
breakthrough infections
vaccines
viral dynamics
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
24
02
2022
accepted:
07
04
2022
entrez:
6
7
2022
pubmed:
7
7
2022
medline:
7
7
2022
Statut:
epublish
Résumé
The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals and the potential for vaccinated individuals to transmit the virus. We examined viral dynamics and infectious virus shedding through daily longitudinal sampling in 23 adults infected with SARS-CoV-2 at varying stages of vaccination, including 6 fully vaccinated individuals. The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases. Vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination.
Sections du résumé
Background
UNASSIGNED
The global effort to vaccinate people against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during an ongoing pandemic has raised questions about how vaccine breakthrough infections compare with infections in immunologically naive individuals and the potential for vaccinated individuals to transmit the virus.
Methods
UNASSIGNED
We examined viral dynamics and infectious virus shedding through daily longitudinal sampling in 23 adults infected with SARS-CoV-2 at varying stages of vaccination, including 6 fully vaccinated individuals.
Results
UNASSIGNED
The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. We also observed that breakthrough infections are associated with strong tissue compartmentalization and are only detectable in saliva in some cases.
Conclusions
UNASSIGNED
Vaccination shortens the duration of time of high transmission potential, minimizes symptom duration, and may restrict tissue dissemination.
Identifiants
pubmed: 35791353
doi: 10.1093/ofid/ofac192
pii: ofac192
pmc: PMC9047214
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofac192Subventions
Organisme : NIAID NIH HHS
ID : R01 AI152703
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI163912
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001422
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001453
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Références
Epidemiology. 2021 Nov 1;32(6):820-828
pubmed: 34469363
Nature. 2022 Feb;602(7898):671-675
pubmed: 35016199
Nat Microbiol. 2022 May;7(5):640-652
pubmed: 35484231
Clin Infect Dis. 2021 Nov 2;73(9):e2861-e2866
pubmed: 33479756
J Infect Dis. 2021 Sep 17;224(6):976-982
pubmed: 34191025
Euro Surveill. 2022 Mar;27(10):
pubmed: 35272744
PLoS Pathog. 2021 Apr 26;17(4):e1009509
pubmed: 33901246
Clin Infect Dis. 2021 Dec 18;:
pubmed: 34922338
EBioMedicine. 2021 Nov;73:103637
pubmed: 34678613
Science. 2022 Mar 11;375(6585):1151-1154
pubmed: 35084937
Emerg Infect Dis. 2020 Jul;26(7):1633-1635
pubmed: 32294051
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7001-7003
pubmed: 32165541
Clin Microbiol Infect. 2022 Apr;28(4):612.e1-612.e7
pubmed: 34826623
Clin Infect Dis. 2021 Aug 16;73(4):e860-e869
pubmed: 33104776
Cell Rep. 2022 May 17;39(7):110829
pubmed: 35550680