A drug discovery approach based on comparative transcriptomics between two toxin-secreting marine annelids:

Animals Drug Discovery Humans Marine Toxins / metabolism Polychaeta / genetics Proteome / metabolism Synthetic Drugs / metabolism Transcriptome

Journal

Molecular omics
ISSN: 2515-4184
Titre abrégé: Mol Omics
Pays: England
ID NLM: 101713384

Informations de publication

Date de publication:
26 09 2022
Historique:
pubmed: 7 7 2022
medline: 28 9 2022
entrez: 6 7 2022
Statut: epublish

Résumé

Most animal toxins evolved to interact with specific molecular targets, which makes them highly-prized bioactives for drug development. Marine toxins, in particular, due to their wide chemical diversity, offer a new range of possibilities, a few of which have already been translated into approved drugs.

Identifiants

DOI: 10.1039/d2mo00138a PMID: 35792046
pubmed: 35792046
doi: 10.1039/d2mo00138a
doi:

Substances chimiques

Marine Toxins 0
Proteome 0
Synthetic Drugs 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

731-744

Auteurs

Inês Moutinho Cabral (I)

Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal. imf.cabral@campus.fct.unl.pt.
UCIBIO - Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal.
ORCID: 0000-0002-7628-8747

Carolina Madeira (C)

Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal. imf.cabral@campus.fct.unl.pt.
UCIBIO - Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal.
ORCID: 0000-0003-1632-634X

Ana R Grosso (AR)

Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal. imf.cabral@campus.fct.unl.pt.
UCIBIO - Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal.
ORCID: 0000-0001-6974-4209

Pedro M Costa (PM)

Associate Laboratory i4HB - Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal. imf.cabral@campus.fct.unl.pt.
UCIBIO - Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal.
ORCID: 0000-0002-9072-3522

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A drug discovery approach based on comparative...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › A drug discovery approach based on comparative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A drug discovery approach based on comparative...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines de la flore et de la faune marines › A drug discovery approach based on comparative...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Annelida › Polychaeta › A drug discovery approach based on comparative...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › A drug discovery approach based on comparative...
questionsmedicales.fr › Préparations pharmaceutiques › Médicaments de synthèse › A drug discovery approach based on comparative...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › A drug discovery approach based on comparative...