HIV nucleoside reverse transcriptase inhibitors.

Anti-HIV Agents / pharmacology Antiretroviral Therapy, Highly Active Drug Resistance, Viral HIV Infections / drug therapy HIV Reverse Transcriptase / metabolism Humans Nucleosides / pharmacology Reverse Transcriptase Inhibitors / pharmacology
HIV Inhibitors Nucleoside Prodrug RT Reverse transcriptase

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
05 Oct 2022
Historique:
received: 01 04 2022
revised: 15 06 2022
accepted: 16 06 2022
pubmed: 7 7 2022
medline: 17 8 2022
entrez: 6 7 2022
Statut: ppublish

Résumé

More than 40 years into the pandemic, HIV remains a global burden and as of now, there is no cure in sight. Fortunately, highly active antiretroviral therapy (HAART) has been developed to manage and suppress HIV infection. Combinations of two to three drugs targeting key viral proteins, including compounds inhibiting HIV reverse transcriptase (RT), have become the cornerstone of HIV treatment. This review discusses nucleoside reverse transcriptase inhibitors (NRTIs), including chain terminators, delayed chain terminators, nucleoside reverse transcriptase translocation inhibitors (NRTTIs), and nucleotide competing RT inhibitors (NcRTIs); focusing on their history, mechanism of action, resistance, and current clinical application, including long-acting regimens.

Identifiants

DOI: 10.1016/j.ejmech.2022.114554 PMID: 35792384
pubmed: 35792384
pii: S0223-5234(22)00456-1
doi: 10.1016/j.ejmech.2022.114554
pii:
doi:

Substances chimiques

Anti-HIV Agents 0
Nucleosides 0
Reverse Transcriptase Inhibitors 0
HIV Reverse Transcriptase EC 2.7.7.49

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

114554

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH116695
Pays : United States

Informations de copyright

Copyright © 2022. Published by Elsevier Masson SAS.

Auteurs

Franck Amblard (F)

Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA, 30322, USA.

Dharmeshkumar Patel (D)

Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA, 30322, USA.

Eleftherios Michailidis (E)

Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA, 30322, USA.

Steven J Coats (SJ)

Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA, 30322, USA.

Mahesh Kasthuri (M)

Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA, 30322, USA.

Nicolas Biteau (N)

Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA, 30322, USA.

Zahira Tber (Z)

Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA, 30322, USA.

Maryam Ehteshami (M)

Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA, 30322, USA.

Raymond F Schinazi (RF)

Center for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, 1760 Haygood Drive, Atlanta, GA, 30322, USA. Electronic address: rschina@emory.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › Agents antiVIH › HIV nucleoside reverse transcriptase inhibitors.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Thérapie antirétrovirale hautement active › HIV nucleoside reverse transcriptase inhibitors.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance virale aux médicaments › HIV nucleoside reverse transcriptase inhibitors.
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › HIV nucleoside reverse transcriptase inhibitors.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines nucléocapside › Protéines du core viral › Produits du gène pol › RNA-directed DNA polymerase › Transcriptase inverse du VIH › HIV nucleoside reverse transcriptase inhibitors.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › HIV nucleoside reverse transcriptase inhibitors.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › HIV nucleoside reverse transcriptase inhibitors.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Inhibiteurs de la transcriptase inverse › HIV nucleoside reverse transcriptase inhibitors.