Liver cirrhosis and immune dysfunction.
acute-on-chronic liver failure (ACLF)
cirrhosis-associated immune dysfunction (CAID)
compensated and decompensated cirrhosis
immune paralysis
inflammation
Journal
International immunology
ISSN: 1460-2377
Titre abrégé: Int Immunol
Pays: England
ID NLM: 8916182
Informations de publication
Date de publication:
06 09 2022
06 09 2022
Historique:
received:
01
05
2022
accepted:
27
06
2022
pubmed:
7
7
2022
medline:
9
9
2022
entrez:
6
7
2022
Statut:
ppublish
Résumé
Cirrhosis is end-stage liver disease resulting from various etiologies and is a common cause of death worldwide. The progression from compensated to decompensated cirrhosis to acute-on-chronic liver failure (ACLF) is due to multiple factors, including continuation of alcohol use or continued exposure to other toxins, an imbalance of the gut microbiota (dysbiosis), increased gut permeability and a disrupted immune response. This disrupted immune response is also named cirrhosis-associated immune dysfunction, which is characterized by worsening systemic inflammation with concomitant immune paralysis, as liver disease deteriorates. This review highlights central immunologic events during the exacerbation of cirrhosis and characterizes the different immune cell populations involved therein.
Identifiants
pubmed: 35792761
pii: 6632640
doi: 10.1093/intimm/dxac030
pmc: PMC9447994
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-466Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK120515
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA011999
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA026939
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA020703
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR001444
Pays : United States
Informations de copyright
Published by Oxford University Press on behalf of The Japanese Society for Immunology 2022.
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