Complement-Opsonized NIR-IIb Emissive Immunotracers for Dynamically Monitoring Neutrophils in Inflammation-Related Diseases.
NIR-II fluorescence imaging
complement C3 opsonization
in vivo tracking
lanthanide-doped nanoparticles
neutrophils
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
revised:
29
06
2022
received:
17
04
2022
pubmed:
7
7
2022
medline:
27
8
2022
entrez:
6
7
2022
Statut:
ppublish
Résumé
Real-time monitoring of neutrophil dynamics is crucial for timely diagnosis and effective treatment of inflammation-related diseases, which requires a reliable tracer for in vivo tracking of neutrophils. However, immunotracers for neutrophils are extremely limited because of the difficulty in labeling the cells. Inspired by the natural biological function of the complement system, a strategy of enhancing the complement C3 opsonization of lanthanide-doped nanoparticles (LnNPs) by modulating their surface chemistry, thus developing a near infrared-IIb emissive nanotracer for neutrophils, is reported herein. Four kinds of surface-modified LnNPs are fabricated, among which phospholipids DOPG-modified LnNPs (LnNPs@PG) with weak antifouling ability and hydroxyl groups adsorb more complement C3 proteins and form covalent linkages with C3b active fragments under inflammation conditions, inducing enhanced complement C3 opsonization. Therefore, LnNPs@PG with enhanced complement C3 opsonization are capable of efficiently labeling inflammation-stimulated neutrophils in vivo through complement-receptors-mediated phagocytosis and achieve dynamic monitoring neutrophils during cutaneous wound healing and cerebral ischemia/reperfusion.
Identifiants
pubmed: 35793262
doi: 10.1002/adma.202203477
doi:
Substances chimiques
Complement C3
0
Opsonin Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2203477Subventions
Organisme : National Natural Science Foundation of China
ID : 21625503
Organisme : Beijing Outstanding Young Scientist Program
ID : BJJWZYJH01201910005017
Organisme : Animal Care and Use Committee of Wuhan University
ID : SYXK 2015-0027
Informations de copyright
© 2022 Wiley-VCH GmbH.
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