The Impact of Reference Data Selection for the Prediction Accuracy of Intrinsic Hepatic Metabolic Clearance.

Hepatocytes / metabolism Humans Kinetics Liver / metabolism Metabolic Clearance Rate Microsomes, Liver / metabolism
Clearance In vitro-in vivo correlation Metabolism Prediction

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
09 2022
Historique:
received: 21 04 2022
revised: 29 06 2022
accepted: 29 06 2022
pubmed: 7 7 2022
medline: 23 8 2022
entrez: 6 7 2022
Statut: ppublish

Résumé

In vitro-in vivo prediction results for hepatic metabolic clearance (CL

Identifiants

DOI: 10.1016/j.xphs.2022.06.024 PMID: 35793746
pubmed: 35793746
pii: S0022-3549(22)00291-X
doi: 10.1016/j.xphs.2022.06.024
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2645-2649

Informations de copyright

Copyright © 2022. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Urban Fagerholm (U)

Prosilico AB, Lännavägen 7, SE-141 45 Huddinge, Sweden. Electronic address: urban.fagerholm@prosilico.com.

Ola Spjuth (O)

Prosilico AB, Lännavägen 7, SE-141 45 Huddinge, Sweden; Department of Pharmaceutical Biosciences and Science for Life Laboratory, Uppsala, University, Box 591, SE-751 24 Uppsala, Sweden.

Sven Hellberg (S)

Prosilico AB, Lännavägen 7, SE-141 45 Huddinge, Sweden.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › The Impact of Reference Data Selection for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Impact of Reference Data Selection for the...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › The Impact of Reference Data Selection for the...
questionsmedicales.fr › Système digestif › Foie › The Impact of Reference Data Selection for the...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Taux de clairance métabolique › The Impact of Reference Data Selection for the...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › The Impact of Reference Data Selection for the...