Biochemical and Endocrine Parameters for the Discrimination and Calibration of Bipolar Disorder or Major Depressive Disorder.
biological markers
bipolar disorder
gender
major depressive disorder
mood disorders
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
03
2022
accepted:
13
05
2022
entrez:
7
7
2022
pubmed:
8
7
2022
medline:
8
7
2022
Statut:
epublish
Résumé
Conventional biochemical indexes may have predictive values in clinical identification between bipolar disorder (BD) and major depressive disorder (MDD). This study included 2,470 (BD/MDD = 1,333/1,137) hospitalized patients in Shanghai as training sets and 2,143 (BD/MDD = 955/1,188) in Hangzhou as test sets. A total of 35 clinical biochemical indexes were tested, including blood cells, immuno-inflammatory factors, liver enzymes, glycemic and lipid parameters, and thyroid and gonadal hormones. A stepwise analysis of a multivariable logistic regression was performed to build a predictive model to identify BD and MDD. Most of these biochemical indexes showed significant differences between BD and MDD groups, such as white blood cell (WBC) in the hematopoietic system, uric acid (UA) in immuno-inflammatory factors, direct bilirubin (DBIL) in liver function, lactic dehydrogenase (LDH) in enzymes, and fasting blood glucose (FBG) and low-density lipoprotein (LDL) in glucolipid metabolism ( Discrimination and calibration were satisfactory, with fair-to-good diagnostic accuracy and external calibration capability in the final prediction models. Female patients may have a higher differentiability with a conventional biochemical index than male patients. ICTRP NCT03949218. Registered on 20 November 2018. Retrospectively registered. https://www.clinicaltrials.gov/ct2/show/NCT03949218?id=NCT03949218&rank=1.
Identifiants
pubmed: 35795028
doi: 10.3389/fpsyt.2022.875141
pmc: PMC9251015
doi:
Banques de données
ClinicalTrials.gov
['NCT03949218']
Types de publication
Journal Article
Langues
eng
Pagination
875141Informations de copyright
Copyright © 2022 Zhu, Ji, Niu, Liu, Wu, Yang, Wang, Chen and Fang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
World J Biol Psychiatry. 2017 Feb;18(1):63-70
pubmed: 26895280
Curr Med Res Opin. 2018 Sep;34(9):1587-1594
pubmed: 29749274
Biol Psychiatry. 2014 Aug 1;76(3):239-48
pubmed: 24199669
Biol Reprod. 2012 Apr 19;86(4):121
pubmed: 22205697
Cell Signal. 2014 Mar;26(3):512-20
pubmed: 24308969
Transl Psychiatry. 2015 Dec 08;5:e689
pubmed: 26645624
Eur Arch Psychiatry Clin Neurosci. 2022 Aug;272(5):817-826
pubmed: 34432143
CNS Neurol Disord Drug Targets. 2017;16(3):257-265
pubmed: 27658510
Am J Obstet Gynecol. 2016 Jun;214(6):714.e1-6
pubmed: 26767792
Lancet Psychiatry. 2016 Dec;3(12):1147-1156
pubmed: 27838212
Epilepsy Res. 2018 Jan;139:20-27
pubmed: 29144993
Clin Chem Lab Med. 2008;46(9):1305-12
pubmed: 18681828
Hum Reprod Update. 2016 Mar-Apr;22(2):182-93
pubmed: 26663221
Hum Reprod Update. 2007 Nov-Dec;13(6):607-16
pubmed: 17895237
Brain Behav Immun. 2014 Jan;35:9-20
pubmed: 24140301
Psychoneuroendocrinology. 2007 Apr;32(3):279-86
pubmed: 17317022
Bipolar Disord. 2019 May;21(3):235-243
pubmed: 30375143
Transl Psychiatry. 2016 Nov 8;6(11):e946
pubmed: 27824355
Br J Clin Pharmacol. 1985 Feb;19(2):239-47
pubmed: 3986082
J Affect Disord. 2013 Sep 25;150(3):923-30
pubmed: 23856278
Behav Brain Res. 2017 Jun 30;329:96-103
pubmed: 28442351
Eur Psychiatry. 2014 Jan;29(1):58-63
pubmed: 23850061
Psychiatry Res. 2016 Mar 30;237:238-45
pubmed: 26805563
J Psychiatr Res. 2016 Oct;81:133-9
pubmed: 27442964
Biol Psychiatry. 2006 Sep 1;60(5):500-6
pubmed: 16487493
Psychiatry Clin Neurosci. 2018 Mar;72(3):180-188
pubmed: 29265573
Oxid Med Cell Longev. 2018 Jul 29;2018:7196142
pubmed: 30151072
J Affect Disord. 2022 Jul 1;308:190-198
pubmed: 35439462
Curr Neuropharmacol. 2018;16(5):519-532
pubmed: 28847296
Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:117-31
pubmed: 25445063
J Affect Disord. 2016 May;195:57-62
pubmed: 26866976
Eur Arch Psychiatry Clin Neurosci. 2018 Mar;268(2):119-127
pubmed: 28620773
Alcohol Clin Exp Res. 2018 Nov;42(11):2094-2099
pubmed: 30091144
J Clin Psychiatry. 2003 Feb;64(2):161-74
pubmed: 12633125
Toxicol In Vitro. 2017 Oct;44:190-195
pubmed: 28712880
J Clin Psychiatry. 2011 Sep;72(9):1207-13
pubmed: 21903033
Theriogenology. 2013 Jan 15;79(2):274-83
pubmed: 23174775
Front Psychiatry. 2020 Feb 27;11:65
pubmed: 32174848
Transl Psychiatry. 2018 Jul 10;8(1):130
pubmed: 29991685
J Psychiatr Res. 2017 Sep;92:119-123
pubmed: 28433948
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):206-11
pubmed: 22750689
Lancet. 2015 Aug 1;386(9992):461-8
pubmed: 26003379
Psychiatry Res. 2017 Jan;247:332-335
pubmed: 27978453
Bipolar Disord. 2013 Mar;15(2):199-205
pubmed: 23437963
Psychiatry Res. 2015 Aug 30;228(3):925-7
pubmed: 26154814
Biomed Res Int. 2020 Oct 22;2020:9124520
pubmed: 33150186
PLoS Med. 2016 Aug 02;13(8):e1002058
pubmed: 27483368
PLoS Med. 2006 Nov;3(11):e428
pubmed: 17090210
Psychoneuroendocrinology. 2019 Sep;107:119-123
pubmed: 31125758
Fertil Steril. 2011 Jun;95(7):2369-72
pubmed: 21497340
Sci Rep. 2016 Jul 06;6:29240
pubmed: 27381978
Ann Epidemiol. 2016 Jul;26(7):482-487.e1
pubmed: 27449569
Neurosci Bull. 2021 Aug;37(8):1176-1187
pubmed: 33909242
Climacteric. 2011 Oct;14(5):602
pubmed: 22016893
Int J Geriatr Psychiatry. 2013 Mar;28(3):242-7
pubmed: 22639424
Am J Psychiatry. 1999 May;156(5):710-5
pubmed: 10327903
Curr Neuropharmacol. 2018;16(5):533-558
pubmed: 29173175
Stat Med. 2013 Jan 15;32(1):67-80
pubmed: 22833304
JAMA Pediatr. 2020 Feb 1;174(2):186-194
pubmed: 31886837
Chin J Integr Med. 2017 Jun;23(6):403-409
pubmed: 28795381