Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia.
Journal
ERJ open research
ISSN: 2312-0541
Titre abrégé: ERJ Open Res
Pays: England
ID NLM: 101671641
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
03
12
2021
accepted:
26
04
2022
entrez:
7
7
2022
pubmed:
8
7
2022
medline:
8
7
2022
Statut:
epublish
Résumé
The incidence of bronchopulmonary dysplasia (BPD) following preterm birth is increasing. Bronchodilators are often used to treat patients with BPD with little evidence to guide therapy. The aim of this study was to test the hypothesis that there are infant pulmonary function test (iPFT) parameters that can predict subsequent bronchodilator response in infants with BPD. Subjects in this study were part of a patient group in which we reported three BPD phenotypes (obstructive, restrictive and mixed) based on iPFT data. From that group, a cohort of 93 patients with iPFT data including bronchodilator response was eligible for this study. Bronchodilator responsiveness was found in 59 people (63%) in the cohort. There were no differences in demographics between the responders and non-responders. There was no difference in forced vital capacity (FVC) between the two groups. Responders had significantly lower forced expiratory volume in 0.5 s (FEV These findings demonstrate that there are pulmonary function test parameters associated with bronchodilator response. Responders had evidence of greater dysanaptic lung growth than non-responders.
Sections du résumé
Background
UNASSIGNED
The incidence of bronchopulmonary dysplasia (BPD) following preterm birth is increasing. Bronchodilators are often used to treat patients with BPD with little evidence to guide therapy. The aim of this study was to test the hypothesis that there are infant pulmonary function test (iPFT) parameters that can predict subsequent bronchodilator response in infants with BPD.
Methods
UNASSIGNED
Subjects in this study were part of a patient group in which we reported three BPD phenotypes (obstructive, restrictive and mixed) based on iPFT data. From that group, a cohort of 93 patients with iPFT data including bronchodilator response was eligible for this study.
Results
UNASSIGNED
Bronchodilator responsiveness was found in 59 people (63%) in the cohort. There were no differences in demographics between the responders and non-responders. There was no difference in forced vital capacity (FVC) between the two groups. Responders had significantly lower forced expiratory volume in 0.5 s (FEV
Conclusion
UNASSIGNED
These findings demonstrate that there are pulmonary function test parameters associated with bronchodilator response. Responders had evidence of greater dysanaptic lung growth than non-responders.
Identifiants
pubmed: 35795305
doi: 10.1183/23120541.00682-2021
pii: 00682-2021
pmc: PMC9251368
pii:
doi:
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright ©The authors 2022.
Déclaration de conflit d'intérêts
Conflict of interest: The authors have no conflicts of interest relevant to this article to disclose.
Références
Respir Physiol Neurobiol. 2018 Jun;252-253:58-63
pubmed: 29588200
J Appl Physiol. 1968 Dec;25(6):664-71
pubmed: 5727191
J Pediatr. 2017 Feb;181:12-28.e1
pubmed: 27908648
J Perinatol. 2015 Jan;35(1):61-6
pubmed: 25102319
Pediatrics. 2018 May;141(5):
pubmed: 29622720
Exp Physiol. 2018 Feb 1;103(2):261-275
pubmed: 29193495
Am J Respir Crit Care Med. 2001 Jan;163(1):91-4
pubmed: 11208631
Am J Respir Crit Care Med. 2019 Sep 15;200(6):751-759
pubmed: 30995069
Pediatr Pulmonol. 2004 Mar;37(3):236-42
pubmed: 14966817
N Engl J Med. 2017 Jul 27;377(4):329-337
pubmed: 28745986
Respir Res. 2019 May 24;20(1):102
pubmed: 31126291
JAMA. 2015 Sep 8;314(10):1039-51
pubmed: 26348753
Respir Physiol Neurobiol. 2016 Jan;220:40-5
pubmed: 26410458
N Engl J Med. 1967 Feb 16;276(7):357-68
pubmed: 5334613
Ann Am Thorac Soc. 2017 Jun 16;14(9):
pubmed: 28622012
Am J Respir Crit Care Med. 2016 Aug 1;194(3):327-32
pubmed: 26840053
Pediatr Pulmonol. 2000 Sep;30(3):215-27
pubmed: 10973040
Res Rep Neonatol. 2015;5:113-117
pubmed: 27812297
Physiol Rev. 2017 Apr;97(2):529-552
pubmed: 28151425
Pediatr Pulmonol. 2019 Aug;54(8):1311-1318
pubmed: 31134768
J Perinatol. 2021 Aug;41(8):1972-1982
pubmed: 33758399
Respir Physiol Neurobiol. 2014 Jul 1;198:25-31
pubmed: 24726854
Am J Respir Crit Care Med. 2001 Aug 1;164(3):447-54
pubmed: 11500348
Am J Respir Crit Care Med. 2005 Dec 1;172(11):1463-71
pubmed: 16301301
N Engl J Med. 1970 Jun 4;282(23):1283-7
pubmed: 5442359
Semin Perinatol. 2013 Apr;37(2):132-7
pubmed: 23582968
Am Rev Respir Dis. 1980 Feb;121(2):339-42
pubmed: 7362140
J Perinatol. 2019 Sep;39(9):1291-1299
pubmed: 31227785
Can Respir J. 2019 Aug 5;2019:5824180
pubmed: 31467619
Int J Chron Obstruct Pulmon Dis. 2016 Oct 07;11:2519-2526
pubmed: 27785008
Pediatr Pulmonol. 1990;9(3):170-6
pubmed: 1980538
Am J Perinatol. 2015 Aug;32(10):960-7
pubmed: 25738785