Analysis of Lymphoma-Related Genes with Gene Ontology and Kyoto Encyclopedia of Genes and Genomes Enrichment.
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
03
2022
revised:
10
05
2022
accepted:
25
05
2022
entrez:
7
7
2022
pubmed:
8
7
2022
medline:
9
7
2022
Statut:
epublish
Résumé
Lymphoma is a serious malignant tumor that contains more than 70 different types and seriously endangers the body's lymphatic system. The lymphatic system is the regulatory center of the immune system and is important in the immune response to foreign antigens and tumors. Studies showed that multiple genetic variants are associated with lymphoma but determining the pathogenic mechanisms remains a challenge. In the present study, we first applied the Gene Ontology (GO) and KEGG pathway enrichment analyses of lymphoma-associated and lymphoma-nonassociated genes. Next, the Boruta and max-relevance and min-redundancy feature selection methods were performed to filter and rank features. Then, features preselected and ranked using the incremental feature selection method were applied for the decision tree model to identify the best GO terms and KEGG pathways and extract classification rules. Results indicate that our predicted features, such as B-cell activation, negative regulation of protein processing, negative regulation of mast cell cytokine production, and natural killer cell-mediated cytotoxicity, are associated with the biological process of lymphoma, consistent with those of recent publications. This study provides a new perspective for future research on the molecular mechanisms of lymphoma.
Identifiants
pubmed: 35795312
doi: 10.1155/2022/8503511
pmc: PMC9251090
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8503511Informations de copyright
Copyright © 2022 Qiao Sun et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
Références
Biomed Res Int. 2022 Jan 13;2022:4035462
pubmed: 35071593
Lung Cancer. 2020 Aug;146:78-85
pubmed: 32521388
Biochim Biophys Acta. 1975 Oct 20;405(2):442-51
pubmed: 1180967
Crit Rev Oncol Hematol. 2014 Aug;91(2):113-22
pubmed: 24629840
Genome Biol. 2007;8(1):R3
pubmed: 17204154
Cell. 2013 Mar 14;152(6):1237-51
pubmed: 23498934
Leukemia. 2019 Jul;33(7):1687-1699
pubmed: 30683910
Cancer Res. 2008 Jul 1;68(13):5439-49
pubmed: 18593947
Cancer Res. 1995 Jul 1;55(13):2730-3
pubmed: 7540948
Adv Exp Med Biol. 2014;816:315-33
pubmed: 24818728
Adv Drug Deliv Rev. 2001 Aug 23;50(1-2):3-20
pubmed: 11489331
Med Clin (Barc). 2019 Jan 18;152(2):65-71
pubmed: 30424932
Annu Rev Immunol. 2017 Apr 26;35:31-52
pubmed: 27860528
Mol Cell Biochem. 2021 Jan;476(1):417-423
pubmed: 32996079
Blood Cancer J. 2017 Jul 7;7(7):e0
pubmed: 28686226
Hematol Oncol Clin North Am. 2019 Feb;33(1):149-161
pubmed: 30497672
Math Biosci Eng. 2022 Feb 10;19(4):3820-3842
pubmed: 35341276
J Immunol. 1982 Sep;129(3):1256-61
pubmed: 6809816
J Clin Pathol. 2001 Jul;54(7):512-6
pubmed: 11429421
N Engl J Med. 2020 Feb 6;382(6):545-553
pubmed: 32023374
Life (Basel). 2022 Jan 31;12(2):
pubmed: 35207515
South Afr J HIV Med. 2018 Nov 07;19(1):809
pubmed: 30473875
Nucleic Acids Res. 2015 Jan;43(Database issue):D1049-56
pubmed: 25428369
Blood. 2002 Jun 1;99(11):4094-9
pubmed: 12010812
Math Biosci. 2018 Dec;306:136-144
pubmed: 30296417
BMC Cancer. 2003 Mar 4;3:6
pubmed: 12614485
Lancet. 2018 Apr 14;391(10129):1524-1537
pubmed: 29477250
Lancet. 2017 Jul 15;390(10091):298-310
pubmed: 28153383
Exp Hematol Oncol. 2012 Nov 29;1(1):36
pubmed: 23210908
J Pathol. 2015 Jan;235(2):312-22
pubmed: 25294567
Nucleic Acids Res. 2016 Jan 4;44(D1):D457-62
pubmed: 26476454
Blood. 2014 Jan 30;123(5):678-86
pubmed: 24326534
Database (Oxford). 2015 Apr 15;2015:bav028
pubmed: 25877637
Science. 2008 Mar 21;319(5870):1676-9
pubmed: 18323416
Front Genet. 2022 Mar 04;13:857851
pubmed: 35309141
Med Clin (Barc). 2018 Feb 9;150(3):104-106
pubmed: 28864087
J Exp Med. 2004 Mar 15;199(6):879-84
pubmed: 15007091
Nat Rev Immunol. 2017 May;17(5):281-294
pubmed: 28368006
Comput Math Methods Med. 2021 Oct 11;2021:7681497
pubmed: 34671418
Curr Oncol Rep. 2015 Jul;17(7):32
pubmed: 26003736
IEEE Trans Pattern Anal Mach Intell. 2005 Aug;27(8):1226-38
pubmed: 16119262
Nurs Stand. 2012 Dec 12-2013 Jan 1;27(15-17):37-42
pubmed: 23346705
Curr Opin Oncol. 2002 Sep;14(5):528-32
pubmed: 12192272
Leuk Lymphoma. 2019 Sep;60(9):2158-2169
pubmed: 30696312