Fibulin-3 Deficiency Protects Against Myocardial Injury Following Ischaemia/ Reperfusion in

Fibulin-3 KO I/R injury cardiac spheroids in vitro cardiac models myocardial infarction reperfusion injury

Journal

Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388

Informations de publication

Date de publication:
2022
Historique:
received: 05 04 2022
accepted: 30 05 2022
entrez: 7 7 2022
pubmed: 8 7 2022
medline: 8 7 2022
Statut: epublish

Résumé

Myocardial infarction (MI, or heart attack) is a leading cause of death worldwide. Myocardial ischaemia reperfusion (I/R) injury typical of MI events is also associated with the development of cardiac fibrosis and heart failure in patients. Fibulin-3 is an extracellular matrix component that plays a role in regulating MI response in the heart. In this study, we generated and compared

Identifiants

pubmed: 35795376
doi: 10.3389/fcvm.2022.913156
pmc: PMC9251181
doi:

Types de publication

Journal Article

Langues

eng

Pagination

913156

Informations de copyright

Copyright © 2022 Sharma, Beck, Murtha, Figtree, Boyle and Gentile.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Poonam Sharma (P)

College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia.
Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia.
Faculty of Medicine and Health, Northern Clinical School, The University of Sydney, Sydney, NSW, Australia.
Faculty of Engineering and IT, School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia.

Dominik Beck (D)

Faculty of Engineering and IT, School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia.

Lucy A Murtha (LA)

College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia.

Gemma Figtree (G)

Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia.
Faculty of Medicine and Health, Northern Clinical School, The University of Sydney, Sydney, NSW, Australia.

Andrew Boyle (A)

College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia.

Carmine Gentile (C)

Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW, Australia.
Faculty of Medicine and Health, Northern Clinical School, The University of Sydney, Sydney, NSW, Australia.
Faculty of Engineering and IT, School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia.

Classifications MeSH