Differentiating pulmonary hypertension associated with protein kinase inhibitors.
cancer
dasatinib
protein kinase
pulmonary arterial hypertension
tyrosine kinase
Journal
Pulmonary circulation
ISSN: 2045-8932
Titre abrégé: Pulm Circ
Pays: United States
ID NLM: 101557243
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
16
12
2021
revised:
14
03
2022
accepted:
25
03
2022
entrez:
7
7
2022
pubmed:
8
7
2022
medline:
8
7
2022
Statut:
epublish
Résumé
Protein kinase inhibitors (PKIs) have been implicated in pulmonary vascular toxicities including risk factors for at least three of the five World Health Organization groups of pulmonary hypertension (PH). These toxicities include direct drug-induced pulmonary arterial hypertension, an increase in cardiomyopathies, and an increase in interstitial lung disease. On- and off-target toxicities are common within multitargeted PKIs leading to cardiopulmonary toxicities. This review highlights the incidence, possible mechanisms, and management strategies for each group of possible PKI-induced PH. Future identification and clarification of protein kinase pathways for both mechanisms of toxicity and pathophysiology for PH could lead to improvements in patient care in oncology and pulmonary vascular diseases.
Identifiants
pubmed: 35795494
doi: 10.1002/pul2.12075
pii: PUL212075
pmc: PMC9248793
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e12075Informations de copyright
© 2022 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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