Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster.
aging
early-life treatment
mTOR
sulfotransferases
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 09 2022
05 09 2022
Historique:
revised:
20
06
2022
received:
25
04
2022
accepted:
23
06
2022
pubmed:
8
7
2022
medline:
9
9
2022
entrez:
7
7
2022
Statut:
ppublish
Résumé
Lifespan is determined by complex and tangled mechanisms that are largely unknown. The early postnatal stage has been proposed to play a role in lifespan, but its contribution is still controversial. Here, we show that a short rapamycin treatment during early life can prolong lifespan in Mus musculus and Drosophila melanogaster. Notably, the same treatment at later time points has no effect on lifespan, suggesting that a specific time window is involved in lifespan regulation. We also find that sulfotransferases are upregulated during early rapamycin treatment both in newborn mice and in Drosophila larvae, and transient dST1 overexpression in Drosophila larvae extends lifespan. Our findings unveil a novel link between early-life treatments and long-term effects on lifespan.
Identifiants
pubmed: 35796299
doi: 10.15252/embr.202255299
pmc: PMC9442325
doi:
Substances chimiques
Drosophila Proteins
0
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e55299Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
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