On the Origin of Sugar Handedness: Facts, Hypotheses and Missing Links-A Review.
Amino acid interactions
Carbohydrates
Homochirality
Prebiotic chemistry
Ribonucleosides
Journal
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life
ISSN: 1573-0875
Titre abrégé: Orig Life Evol Biosph
Pays: Netherlands
ID NLM: 8610391
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
05
02
2022
accepted:
24
05
2022
pubmed:
8
7
2022
medline:
5
10
2022
entrez:
7
7
2022
Statut:
ppublish
Résumé
By paraphrasing one of Kipling's most amazing short stories (How the Leopard Got His Spots), this article could be entitled "How Sugars Became Homochiral". Obviously, we have no answer to this still unsolved mystery, and this perspective simply brings recent models, experiments and hypotheses into the homochiral homogeneity of sugars on earth. We shall revisit the past and current understanding of sugar chirality in the context of prebiotic chemistry, with attention to recent developments and insights. Different scenarios and pathways will be discussed, from the widely known formose-type processes to less familiar ones, often viewed as unorthodox chemical routes. In particular, problems associated with the spontaneous generation of enantiomeric imbalances and the transfer of chirality will be tackled. As carbohydrates are essential components of all cellular systems, astrochemical and terrestrial observations suggest that saccharides originated from environmentally available feedstocks. Such substances would have been capable of sustaining autotrophic and heterotrophic mechanisms integrating nutrients, metabolism and the genome after compartmentalization. Recent findings likewise indicate that sugars' enantiomeric bias may have emerged by a transfer of chirality mechanisms, rather than by deracemization of sugar backbones, yet providing an evolutionary advantage that fueled the cellular machinery.
Identifiants
pubmed: 35796896
doi: 10.1007/s11084-022-09624-9
pii: 10.1007/s11084-022-09624-9
doi:
Substances chimiques
Carbohydrates
0
Sugars
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
21-56Subventions
Organisme : Junta de Extremadura and European Regional Development Fund
ID : Grant GR21039
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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