Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment.
Biological aging
Comprehensive geriatric assessment
Frailty
Multidimensional prognostic index
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
29
10
2021
accepted:
19
06
2022
pubmed:
8
7
2022
medline:
23
12
2022
entrez:
7
7
2022
Statut:
ppublish
Résumé
Measuring intrinsic, biological age is a central question in medicine, which scientists have been trying to answer for decades. Age manifests itself differently in different individuals, and chronological age often does not reflect such heterogeneity of health and function. We discuss here the value of measuring age and aging using the comprehensive geriatric assessment (CGA), cornerstone of geriatric medicine, and operationalized assessment tools for prognosis. Specifically, we review the benefits of employing the multidimensional prognostic index (MPI), which collects information about eight domains relevant for the global assessment of the older person (functional and cognitive status, nutrition, mobility and risk of pressure sores, multi-morbidity, polypharmacy, and co-habitation), in the evaluation of the functional status, and in the prediction of health outcomes for older adults. Further integration of biological markers of aging into multidimensional prognostic tools is warranted, as well as actions which could facilitate prognostic assessments for older persons in all healthcare settings.
Identifiants
pubmed: 35796977
doi: 10.1007/s11357-022-00613-4
pii: 10.1007/s11357-022-00613-4
pmc: PMC9261220
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2611-2622Informations de copyright
© 2022. The Author(s).
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