Chemical constituents of Antidesma bunius aerial parts and the anti-AGEs activity of selected compounds.
Advanced glycation endproducts
Antidesma bunius
Coumarinolignan
Cyclopeptide
Euphorbiaceae
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
08
03
2022
revised:
21
06
2022
accepted:
27
06
2022
pubmed:
8
7
2022
medline:
8
9
2022
entrez:
7
7
2022
Statut:
ppublish
Résumé
Thirty-three natural products were isolated from the aerial parts of Antidesma bunius, Euphorbiaceae, a plant used in Vietnamese traditional medicine against rheumatoid arthritis. All compounds were reported the first time for this species, and nine constituents resembled undescribed natural products, noticeably three coumarinolignans with 2,2-dimethyl-1,3-dioxolane moiety, two cyclopeptides, and two furofuran-type lignans connected with a phenylpropanoid moiety. The individual structures were elucidated by combining NMR and MS data, and their configuration was established by NOESY and ECD experiments and NMR calculations. Compounds with sufficient amount were analyzed for their inhibition of advanced glycation endproducts (AGEs) formation, metabolites involved in many diseases like Alzheimer, joint diseases or diabetes. With IC
Identifiants
pubmed: 35798090
pii: S0031-9422(22)00216-3
doi: 10.1016/j.phytochem.2022.113300
pii:
doi:
Substances chimiques
Biological Products
0
Glycation End Products, Advanced
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113300Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.