Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats.

ATP Binding Cassette Transporter, Subfamily B / metabolism ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 / metabolism ATP-Binding Cassette Transporters / metabolism Animals Blood-Brain Barrier / metabolism Brain / metabolism Erlotinib Hydrochloride Lung / diagnostic imaging Neoplasm Proteins / metabolism Positron-Emission Tomography / methods Rats
Blood-brain barrier, positron emission tomography Breast cancer resistance protein Lung epithelial barrier P-glycoprotein Pulmonary drug delivery

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
09 2022
Historique:
received: 18 01 2022
revised: 21 06 2022
accepted: 29 06 2022
pubmed: 8 7 2022
medline: 21 9 2022
entrez: 7 7 2022
Statut: ppublish

Résumé

P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two efflux transporters which are expressed in the apical (i.e. airway lumen-facing) membranes of lung epithelial cells. To assess the influence of P-gp and BCRP on the pulmonary disposition of inhaled drugs, we performed positron emission tomography (PET) imaging in rats after intratracheal aerosolization of two model P-gp/BCRP substrate radiotracers (i.e. [

Identifiants

DOI: 10.1016/j.jconrel.2022.06.065 PMID: 35798092
pubmed: 35798092
pii: S0168-3659(22)00407-2
doi: 10.1016/j.jconrel.2022.06.065
pii:
doi:

Substances chimiques

ATP Binding Cassette Transporter, Subfamily B 0
ATP Binding Cassette Transporter, Subfamily B, Member 1 0
ATP Binding Cassette Transporter, Subfamily G, Member 2 0
ATP-Binding Cassette Transporters 0
Neoplasm Proteins 0
Erlotinib Hydrochloride DA87705X9K

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109-117

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interests.

Auteurs

Severin Mairinger (S)

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Irene Hernández-Lozano (I)

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Thomas Filip (T)

Core Facility Laboratory Animal Breeding and Husbandry, Medical University of Vienna, Vienna, Austria.

Michael Sauberer (M)

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Mathilde Löbsch (M)

Core Facility Laboratory Animal Breeding and Husbandry, Medical University of Vienna, Vienna, Austria.

Johann Stanek (J)

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Thomas Wanek (T)

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Johannes A Sake (JA)

School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

Thomas Pekar (T)

Biomedical Sciences, University of Applied Sciences Wiener Neustadt, Wiener Neustadt, Austria.

Carsten Ehrhardt (C)

School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland. Electronic address: EHRHARDC@tcd.ie.

Oliver Langer (O)

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. Electronic address: oliver.langer@meduniwien.ac.at.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Sous-famille B de transporteurs à cassette liant l'ATP › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Sous-famille B de transporteurs à cassette liant l'ATP › Glycoprotéine P › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Sous-famille G des transporteurs à cassette liant l'ATP › Membre-2 de la sous-famille G des transporteurs à cassette liant l'ATP › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Eucaryotes › Animaux › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinazolines › Chlorhydrate d'erlotinib › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Appareil respiratoire › Poumon › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Impact of P-gp and BCRP on pulmonary drug...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Impact of P-gp and BCRP on pulmonary drug...