Impact of

Amino Acid Transport Systems / metabolism Biological Transport HEK293 Cells Humans Mercaptopurine / pharmacology Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

Journal

The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362

Informations de publication

Date de publication:
09 2022
Historique:
received: 04 02 2022
accepted: 24 06 2022
pubmed: 8 7 2022
medline: 30 8 2022
entrez: 7 7 2022
Statut: ppublish

Résumé

6-Mercaptopurine (6-MP) is used extensively in the treatment of acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases. Our laboratory determined previously, using a recombinant HEK293 cell model, that the

Identifiants

DOI: 10.1124/jpet.122.001155 PMID: 35798387
pubmed: 35798387
pii: jpet.122.001155
doi: 10.1124/jpet.122.001155
doi:

Substances chimiques

Amino Acid Transport Systems 0
SLC43A3 protein, human 0
Mercaptopurine E7WED276I5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

335-345

Subventions

Organisme : CIHR
ID : 168913
Pays : Canada

Informations de copyright

Copyright © 2022 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Nicholas M Ruel (NM)

Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.

Khanh Hoa Nguyen (KH)

Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.
ORCID: 0000-0001-5096-1342

Chan S Kim (CS)

Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.

Laura P S Andrade (LPS)

Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada.

James R Hammond (JR)

Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada james.hammond@ualberta.ca.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Systèmes de transport d'acides aminés › Impact of
questionsmedicales.fr › Métabolisme › Transport biologique › Impact of
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Impact of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Impact of
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Mercaptopurine › Impact of
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Impact of