Comparison of cone bioassay estimates at two laboratories with different Anopheles mosquitoes for quality assurance of pyrethroid insecticide-treated nets.

Animals Anopheles Biological Assay / methods Insecticide Resistance Insecticide-Treated Bednets Insecticides / pharmacology Laboratories Malaria / prevention & control Mosquito Control / methods Pyrethrins / pharmacology
Anopheles Bioassay Bioefficacy Cone bioassay ITN Insecticide treated nets LLIN Long lasting insecticidal nets Malaria Mosquito Pyrethroid Quality assurance Tunnel test

Journal

Malaria journal
ISSN: 1475-2875
Titre abrégé: Malar J
Pays: England
ID NLM: 101139802

Informations de publication

Date de publication:
07 Jul 2022
Historique:
received: 17 01 2022
accepted: 11 06 2022
entrez: 7 7 2022
pubmed: 8 7 2022
medline: 12 7 2022
Statut: epublish

Résumé

Quality assurance (QA) of insecticide-treated nets (ITNs) delivered to malaria-endemic countries is conducted by measuring physiochemical parameters, but not bioefficacy against malaria mosquitoes. This study explored utility of cone bioassays for pre-delivery QA of pyrethroid ITNs to test the assumption that cone bioassays are consistent across locations, mosquito strains, and laboratories. Double-blinded bioassays were conducted on twenty unused pyrethroid ITNs of 4 brands (100 nets, 5 subsamples per net) that had been delivered for mass distribution in Papua New Guinea (PNG) having passed predelivery inspections. Cone bioassays were performed on the same net pieces following World Health Organization (WHO) guidelines at the PNG Institute of Medical Research (PNGIMR) using pyrethroid susceptible Anopheles farauti sensu stricto (s.s.) and at Ifakara Health Institute (IHI), Tanzania using pyrethroid susceptible Anopheles gambiae s.s. Additionally, WHO tunnel tests were conducted at IHI on ITNs that did not meet cone bioefficacy thresholds. Results from IHI and PNGIMR were compared using Spearman's Rank correlation, Bland-Altman (BA) analysis and analysis of agreement. Literature review on the use of cone bioassays for unused pyrethroid ITNs testing was conducted. In cone bioassays, 13/20 nets (65%) at IHI and 8/20 (40%) at PNGIMR met WHO bioefficacy criteria. All nets met WHO bioefficacy criteria on combined cone/tunnel tests at IHI. Results from IHI and PNGIMR correlated on 60-min knockdown (KD60) (r Based on these study findings, the WHO cone bioassay is a reproducible bioassay for ITNs with > 80% M24, and for all ITNs provided inherent stochastic variation and systematic bias are accounted for. The literature review confirms that WHO cone bioassay bioefficacy criteria have been previously achieved by all pyrethroid ITNs (unwashed), without the need for additional tunnel tests. The 80% M24 threshold remains the most reliable indicator of pyrethroid ITN quality using pyrethroid susceptible mosquitoes. In the absence of alternative tests, cone bioassays could be used as part of pre-delivery QA.

Sections du résumé

BACKGROUND BACKGROUND
Quality assurance (QA) of insecticide-treated nets (ITNs) delivered to malaria-endemic countries is conducted by measuring physiochemical parameters, but not bioefficacy against malaria mosquitoes. This study explored utility of cone bioassays for pre-delivery QA of pyrethroid ITNs to test the assumption that cone bioassays are consistent across locations, mosquito strains, and laboratories.
METHODS METHODS
Double-blinded bioassays were conducted on twenty unused pyrethroid ITNs of 4 brands (100 nets, 5 subsamples per net) that had been delivered for mass distribution in Papua New Guinea (PNG) having passed predelivery inspections. Cone bioassays were performed on the same net pieces following World Health Organization (WHO) guidelines at the PNG Institute of Medical Research (PNGIMR) using pyrethroid susceptible Anopheles farauti sensu stricto (s.s.) and at Ifakara Health Institute (IHI), Tanzania using pyrethroid susceptible Anopheles gambiae s.s. Additionally, WHO tunnel tests were conducted at IHI on ITNs that did not meet cone bioefficacy thresholds. Results from IHI and PNGIMR were compared using Spearman's Rank correlation, Bland-Altman (BA) analysis and analysis of agreement. Literature review on the use of cone bioassays for unused pyrethroid ITNs testing was conducted.
RESULTS RESULTS
In cone bioassays, 13/20 nets (65%) at IHI and 8/20 (40%) at PNGIMR met WHO bioefficacy criteria. All nets met WHO bioefficacy criteria on combined cone/tunnel tests at IHI. Results from IHI and PNGIMR correlated on 60-min knockdown (KD60) (r
CONCLUSIONS CONCLUSIONS
Based on these study findings, the WHO cone bioassay is a reproducible bioassay for ITNs with > 80% M24, and for all ITNs provided inherent stochastic variation and systematic bias are accounted for. The literature review confirms that WHO cone bioassay bioefficacy criteria have been previously achieved by all pyrethroid ITNs (unwashed), without the need for additional tunnel tests. The 80% M24 threshold remains the most reliable indicator of pyrethroid ITN quality using pyrethroid susceptible mosquitoes. In the absence of alternative tests, cone bioassays could be used as part of pre-delivery QA.

Identifiants

DOI: 10.1186/s12936-022-04217-3 PMID: 35799172 PMC: PMC9264565
pubmed: 35799172
doi: 10.1186/s12936-022-04217-3
pii: 10.1186/s12936-022-04217-3
pmc: PMC9264565
doi:

Substances chimiques

Insecticides 0
Pyrethrins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

214

Subventions

Organisme : National Health and Medical Research Council
ID : GNT1141441

Informations de copyright

© 2022. The Author(s).

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Auteurs

Stephen G Mbwambo (SG)

Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Science Department, Ifakara Health Institute, Bagamoyo, Tanzania. smbwambo@ihi.or.tz.
Nelson Mandela Africa Institution of Science and Technology, Arusha, Tanzania. smbwambo@ihi.or.tz.
Sokoine RRH, Ministry of Health, Lindi, Tanzania. smbwambo@ihi.or.tz.
Regional Health Management Team, P.O Box 1011, Lindi, Tanzania. smbwambo@ihi.or.tz.

Nakei Bubun (N)

Vector Borne Disease Unit, PNG Institute of Medical Research, Madang Province 511, P.O Box 378, Madang, Papua New Guinea.

Emmanuel Mbuba (E)

Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Science Department, Ifakara Health Institute, Bagamoyo, Tanzania.
University of Basel, Basel, Switzerland.
Vector Biology Unit, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute (Swiss TPH, Allschwil, Kreuzstrasse 2, 4123, , Basel, Switzerland.

Jason Moore (J)

Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Science Department, Ifakara Health Institute, Bagamoyo, Tanzania.
Vector Biology Unit, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute (Swiss TPH, Allschwil, Kreuzstrasse 2, 4123, , Basel, Switzerland.

Kasiani Mbina (K)

Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Science Department, Ifakara Health Institute, Bagamoyo, Tanzania.

Dismas Kamande (D)

Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Science Department, Ifakara Health Institute, Bagamoyo, Tanzania.
Nelson Mandela Africa Institution of Science and Technology, Arusha, Tanzania.

Moses Laman (M)

Vector Borne Disease Unit, PNG Institute of Medical Research, Madang Province 511, P.O Box 378, Madang, Papua New Guinea.

Emmanuel Mpolya (E)

Nelson Mandela Africa Institution of Science and Technology, Arusha, Tanzania.

Olukayode G Odufuwa (OG)

Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Science Department, Ifakara Health Institute, Bagamoyo, Tanzania.
University of Basel, Basel, Switzerland.
Vector Biology Unit, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute (Swiss TPH, Allschwil, Kreuzstrasse 2, 4123, , Basel, Switzerland.
MRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Tim Freeman (T)

Rotarian Against Malaria, P.O Box 3686, Boroko, NCD 111, Papua New Guinea.

Stephan Karl (S)

Vector Borne Disease Unit, PNG Institute of Medical Research, Madang Province 511, P.O Box 378, Madang, Papua New Guinea.
Australian Institute of Tropical Health and Medicine, James Cook University, 1/14-88 McGregor Road, Smithfield, QLD, 4870, Australia.

Sarah J Moore (SJ)

Vector Control Product Testing Unit (VCPTU), Environmental Health and Ecological Science Department, Ifakara Health Institute, Bagamoyo, Tanzania.
Nelson Mandela Africa Institution of Science and Technology, Arusha, Tanzania.
University of Basel, Basel, Switzerland.
Vector Biology Unit, Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute (Swiss TPH, Allschwil, Kreuzstrasse 2, 4123, , Basel, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Comparison of cone bioassay estimates at two...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicidae › Anopheles › Comparison of cone bioassay estimates at two...
questionsmedicales.fr › Techniques d'investigation › Dosage biologique › Comparison of cone bioassay estimates at two...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux insecticides › Comparison of cone bioassay estimates at two...
questionsmedicales.fr › Équipement et fournitures › Moustiquaires de lit traitées aux insecticides › Comparison of cone bioassay estimates at two...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Insecticides › Comparison of cone bioassay estimates at two...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Établissements de santé › Laboratoires › Comparison of cone bioassay estimates at two...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Comparison of cone bioassay estimates at two...
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