Role of HIF-1α/ERRα in Enhancing Cancer Cell Metabolism and Promoting Resistance of Endometrial Cancer Cells to Pyroptosis.
ERRα
HIF-1α
endometrial cancer
glucose metabolism
lipid metabolism
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2022
2022
Historique:
received:
22
02
2022
accepted:
25
05
2022
entrez:
8
7
2022
pubmed:
9
7
2022
medline:
9
7
2022
Statut:
epublish
Résumé
Oxygen is critical to energy metabolism, and tumors are often characterized by a hypoxic microenvironment. Owing to the high metabolic energy demand of malignant tumor cells, their survival is promoted by metabolic reprogramming in the hypoxic microenvironment, which can confer tumor cell resistance to pyroptosis. Pyroptosis resistance can inhibit anti-tumor immunity and promote the development of malignant tumors. Hypoxia inducible factor-1α (HIF-1α) is a key regulator of metabolic reprogramming in tumor cells, and estrogen-related receptor α (ERRα) plays a key role in regulating cellular energy metabolism. Therefore, the close interaction between HIF-1α and ERRα influences the metabolic and functional changes in cancer cells. In this review, we summarize the reprogramming of tumor metabolism involving HIF-1α/ERRα. We review our understanding of the role of HIF-1α/ERRα in promoting tumor growth adaptation and pyroptosis resistance, emphasize its key role in energy homeostasis, and explore the regulation of HIF-1α/ERRα in preventing and/or treating endometrial carcinoma patients. This review provides a new perspective for the study of the molecular mechanisms of metabolic changes in tumor progression.
Identifiants
pubmed: 35800058
doi: 10.3389/fonc.2022.881252
pmc: PMC9253301
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
881252Informations de copyright
Copyright © 2022 Su, Yu, Mao and Sun.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Br J Cancer. 2013 Sep 17;109(6):1703-10
pubmed: 23949151
Phytomedicine. 2020 Nov;78:153318
pubmed: 32896707
Lab Invest. 2011 Jun;91(6):859-71
pubmed: 21537326
NPJ Precis Oncol. 2019 Mar 21;3:9
pubmed: 30911677
Int J Biol Macromol. 2020 May 15;151:1277-1286
pubmed: 31751687
Int J Gen Med. 2021 Nov 12;14:8073-8085
pubmed: 34803394
Front Pharmacol. 2019 Mar 22;10:260
pubmed: 30967777
Theranostics. 2021 Aug 12;11(18):8813-8835
pubmed: 34522213
Oral Oncol. 2018 May;80:23-32
pubmed: 29706185
Gynecol Oncol. 1983 Feb;15(1):10-7
pubmed: 6822361
Tissue Cell. 2008 Dec;40(6):405-10
pubmed: 18579174
BMC Cancer. 2010 Jun 19;10:307
pubmed: 20565904
N Engl J Med. 2020 Nov 19;383(21):2053-2064
pubmed: 33207095
Int J Oncol. 2021 Jul;59(1):
pubmed: 34132354
BMC Cancer. 2017 Sep 6;17(1):631
pubmed: 28877685
Biochim Biophys Acta Rev Cancer. 2018 Aug;1870(1):51-66
pubmed: 29959989
BMC Cancer. 2017 Sep 8;17(1):638
pubmed: 28886696
Front Cell Dev Biol. 2021 Oct 14;9:705828
pubmed: 34722500
Biosci Rep. 2020 Jan 31;40(1):
pubmed: 31894856
J Steroid Biochem Mol Biol. 2009 Aug;116(1-2):71-5
pubmed: 19416752
Nat Rev Cancer. 2016 Nov;16(11):732-749
pubmed: 27658529
Cell Physiol Biochem. 2017;41(6):2374-2382
pubmed: 28467979
Acta Pharmacol Sin. 2015 Jan;36(1):51-61
pubmed: 25500872
Tumour Biol. 2016 May;37(5):6035-44
pubmed: 26602383
J Hepatol. 2021 Jun;74(6):1373-1385
pubmed: 33484774
BMC Med Genet. 2019 Dec 21;20(1):202
pubmed: 31864301
FEBS J. 2015 Feb;282(4):647-72
pubmed: 25495651
J Biol Chem. 2017 Oct 13;292(41):16825-16832
pubmed: 28842498
Aging (Albany NY). 2020 Nov 10;12(22):23029-23046
pubmed: 33197888
Nat Commun. 2016 Jul 12;7:12156
pubmed: 27402251
Cell Adh Migr. 2018;12(6):538-547
pubmed: 29781387
Cancer Res. 2011 Sep 1;71(17):5728-38
pubmed: 21734015
CA Cancer J Clin. 2020 Jan;70(1):7-30
pubmed: 31912902
Cell Rep. 2018 Sep 4;24(10):2596-2605.e5
pubmed: 30184495
Sci Rep. 2019 Apr 30;9(1):6697
pubmed: 31040369
J Cell Biochem. 2018 Nov 11;:
pubmed: 30417413
Oncogene. 2013 Jul 25;32(30):3483-90
pubmed: 23208510
Cancer Lett. 2021 Jul 28;511:77-87
pubmed: 33961924
J Biol Chem. 2006 Dec 29;281(52):39897-906
pubmed: 17079227
Int J Mol Sci. 2020 Jul 31;21(15):
pubmed: 32751958
J Clin Oncol. 2011 Jun 1;29(16):2259-65
pubmed: 21537039
Cell Immunol. 2021 Sep;367:104409
pubmed: 34246872
Cancer Manag Res. 2018 Dec 12;10:6887-6895
pubmed: 30588094
Analyst. 2019 Sep 9;144(18):5558-5570
pubmed: 31408068
Cancer. 2016 Sep 15;122(18):2787-98
pubmed: 27308732
Exp Ther Med. 2021 Jun;21(6):584
pubmed: 33850556
Eur J Med Chem. 2017 Sep 29;138:830-853
pubmed: 28735214
FEBS J. 2016 Aug;283(15):2767-78
pubmed: 26881388
Cell Rep. 2014 Oct 9;9(1):349-365
pubmed: 25263561
CA Cancer J Clin. 2021 Jan;71(1):7-33
pubmed: 33433946
Front Endocrinol (Lausanne). 2019 Apr 05;10:206
pubmed: 31024446
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1142-1152
pubmed: 29908837
Cell Rep. 2016 Apr 12;15(2):323-35
pubmed: 27050525
Cell Rep. 2016 Feb 2;14(4):920-931
pubmed: 26804918
JAMA Oncol. 2015 Dec;1(9):1319-23
pubmed: 26181000
Aging (Albany NY). 2020 Sep 13;12(17):16963-16980
pubmed: 32920551
Cell. 2013 Jan 31;152(3):599-611
pubmed: 23374352
Cell Stem Cell. 2015 May 7;16(5):547-55
pubmed: 25865501
Arch Biochem Biophys. 2020 May 15;684:108327
pubmed: 32142890
BMC Cancer. 2020 Sep 7;20(1):864
pubmed: 32894095
Cancers (Basel). 2021 May 26;13(11):
pubmed: 34073320
Cancer Metab. 2013 Dec 05;1(1):22
pubmed: 24304688
Cancer Manag Res. 2018 Aug 10;10:2521-2535
pubmed: 30127640
Anticancer Res. 2006 Mar-Apr;26(2C):1699-706
pubmed: 16617564
Cells. 2020 Jul 23;9(8):
pubmed: 32717915
Onco Targets Ther. 2019 Aug 20;12:6757-6767
pubmed: 31686835
Hum Cell. 2020 Jul;33(3):790-800
pubmed: 32304027
Cancers (Basel). 2020 Dec 31;13(1):
pubmed: 33396270
Nat Rev Cancer. 2013 Jan;13(1):27-36
pubmed: 23192231
Carcinogenesis. 2013 Oct;34(10):2253-61
pubmed: 23720198
Metabolites. 2021 Jan 02;11(1):
pubmed: 33401771
Onco Targets Ther. 2020 Dec 22;13:13055-13062
pubmed: 33376354
Am J Pathol. 2021 Jul;191(7):1240-1254
pubmed: 33894178
BMC Cancer. 2020 Jan 10;20(1):28
pubmed: 31924176
Cancers (Basel). 2021 May 26;13(11):
pubmed: 34073635
Semin Cancer Biol. 2019 Dec;59:125-132
pubmed: 31323288
Life Sci. 2020 Sep 15;257:118065
pubmed: 32659366
Front Oncol. 2021 Jun 03;11:656851
pubmed: 34150624
Front Oncol. 2020 Aug 28;10:1474
pubmed: 33014785
Front Genet. 2021 Oct 12;12:755384
pubmed: 34712271
J Exp Clin Cancer Res. 2018 Sep 5;37(1):218
pubmed: 30185207
Int J Gynecol Cancer. 2006 Mar-Apr;16(2):827-33
pubmed: 16681769
Acta Chim Slov. 2017 Sep;64(3):549-554
pubmed: 28862289
Cells. 2020 Jul 31;9(8):
pubmed: 32751976
Cell Signal. 2020 Sep;73:109688
pubmed: 32512041
Mod Pathol. 2006 Jan;19(1):9-16
pubmed: 16258506
J Clin Oncol. 2017 Aug 1;35(22):2535-2541
pubmed: 28489510
Cancer. 2002 Sep 1;95(5):1055-63
pubmed: 12209691
Int J Mol Sci. 2020 Sep 29;21(19):
pubmed: 33003368
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6556-E6565
pubmed: 28739932
Cell Oncol (Dordr). 2019 Apr;42(2):223-235
pubmed: 30706380
Front Oncol. 2021 May 11;11:653596
pubmed: 34046349
Biomed Res Int. 2020 Jun 20;2020:9243681
pubmed: 32685545
Cancer Lett. 2020 Jan 28;469:89-101
pubmed: 31639424
ACS Chem Biol. 2020 Sep 18;15(9):2338-2345
pubmed: 32897058
J Pathol. 2014 May;233(1):61-73
pubmed: 24425001
Minerva Med. 2021 Feb;112(1):81-95
pubmed: 33104302
Curr Mol Med. 2018;18(6):343-351
pubmed: 30411685
Int J Gynecol Cancer. 2021 Apr;31(4):530-536
pubmed: 33361459
Cancer Res. 2020 Apr 15;80(8):1748-1761
pubmed: 32054768
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Cell Rep. 2019 Jun 18;27(12):3587-3601.e4
pubmed: 31216477
Dev Cell. 2021 May 17;56(10):1363-1393
pubmed: 33945792
Oncotarget. 2016 Jun 7;7(23):34131-48
pubmed: 27153547
Cancer Biother Radiopharm. 2020 Aug 18;:
pubmed: 32818382
Am J Cancer Res. 2020 Dec 01;10(12):4112-4122
pubmed: 33414989
J Exp Clin Cancer Res. 2022 Jan 19;41(1):28
pubmed: 35045880
Cancer Lett. 2016 Apr 1;373(1):36-44
pubmed: 26801746
J Mol Med (Berl). 2005 Jun;83(6):457-67
pubmed: 15770498
Jpn J Clin Oncol. 2019 Feb 1;49(2):108-120
pubmed: 30423148
Cochrane Database Syst Rev. 2019 Oct 07;10:CD012160
pubmed: 31588998
Med Sci Monit. 2020 Jul 22;26:e924328
pubmed: 32696762
Trends Cancer. 2016 Dec;2(12):758-770
pubmed: 28741521
Mol Cancer Res. 2019 Nov;17(11):2184-2195
pubmed: 31427441
Front Oncol. 2019 Aug 08;9:744
pubmed: 31440472
Genes Dis. 2019 Oct 03;7(2):172-184
pubmed: 32215287
Proc Natl Acad Sci U S A. 2013 May 28;110(22):8882-7
pubmed: 23671091
Mol Med Rep. 2008 Nov-Dec;1(6):917-24
pubmed: 21479506
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1260-1272
pubmed: 28735096