Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis.


Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2022
Historique:
received: 22 03 2022
accepted: 06 05 2022
entrez: 8 7 2022
pubmed: 9 7 2022
medline: 12 7 2022
Statut: epublish

Résumé

Bone marrow adipocytes (BMAs) represent 10% of the total fat mass of the human body and serve as an energy reservoir for the skeletal niche. They function as an endocrine organ by actively secreting fatty acids, cytokines, and adipokines. The volume of BMAs increases along with age, osteoporosis and/or obesity. With the rapid development of multi-omic analysis and the advance in

Identifiants

pubmed: 35800430
doi: 10.3389/fendo.2022.902033
pmc: PMC9253270
doi:

Substances chimiques

Adipokines 0
Fatty Acids 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

902033

Informations de copyright

Copyright © 2022 Li, Cao, Gaculenko, Zhan, Bozec and Chen.

Déclaration de conflit d'intérêts

Author YZ is employed by company Shanghai Huaota Biopharmaceutical Co. Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Yixuan Li (Y)

Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Shan Cao (S)

Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.

Anastasia Gaculenko (A)

Department of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.

Yifan Zhan (Y)

Drug Discovery, Shanghai Huaota Biopharmaceutical Co. Ltd., Shanghai, China.

Aline Bozec (A)

Department of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.

Xiaoxiang Chen (X)

Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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Classifications MeSH