Oral nifedipine and parenteral isoxsuprine in arresting preterm labor: A comparative study.
Gestational Age
isoxsuprine
nifedipine
pregnancy
tocolysis
Journal
Journal of family medicine and primary care
ISSN: 2249-4863
Titre abrégé: J Family Med Prim Care
Pays: India
ID NLM: 101610082
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
19
08
2020
revised:
27
10
2020
accepted:
04
02
2022
entrez:
8
7
2022
pubmed:
9
7
2022
medline:
9
7
2022
Statut:
ppublish
Résumé
To compare the efficacy of oral nifedipine and parenteral isoxsuprine in arresting preterm labor. Considering the paucity of studies comparing these two agents, a comparative analysis is obligatory. Eighty antenatal women in the gestational age range of 28-37 weeks, with regular uterine contractions, cervical dilatation ≤3 cm, and <50% cervical effacement, admitted with complaints of preterm labor pain were randomized to receive either 40 mg isoxsuprine or 20 mg nifedipine. Efficacy of the drugs was measured in terms of arrest of preterm labor, prolongation of pregnancy, and the days gained by infant before birth. Isoxsuprine showed increased lowering of systolic blood pressure (SBP), diastolic blood pressure (DBP), and slightly higher maternal pulse rate, but higher fetal pulse rate post-administration in comparison to nifedipine ( Nifedipine was slightly more effective in arresting preterm labor with fewer side effects, compared to isoxsuprine.
Identifiants
pubmed: 35800477
doi: 10.4103/jfmpc.jfmpc_1696_20
pii: JFMPC-11-1845
pmc: PMC9254824
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1845-1850Informations de copyright
Copyright: © 2022 Journal of Family Medicine and Primary Care.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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