Impaired interferon-γ signaling promotes the development of silicosis.
Molecular biology
Molecular physiology
Physiology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
15 Jul 2022
15 Jul 2022
Historique:
received:
22
02
2022
revised:
18
05
2022
accepted:
15
06
2022
entrez:
8
7
2022
pubmed:
9
7
2022
medline:
9
7
2022
Statut:
epublish
Résumé
Silicosis is caused by inhalation of crystalline silica dust particles and known as one of the most serious occupational diseases worldwide. However, little is known about intrinsic factors leading to disease susceptibility. Single-cell sequencing of bronchoalveolar lavage fluid cells of mine workers with silicosis and their co-workers who did not develop silicosis revealed that the impaired interferon (IFN)-γ signaling in myeloid cells was strongly associated with the occurrence of silicosis. Global or myeloid cell-specific deletion of interferon γ receptor (IFN-γR) markedly enhanced the crystalline silica-induced pulmonary injury in wild-type but not in NLRP3 deficient mice.
Identifiants
pubmed: 35800765
doi: 10.1016/j.isci.2022.104647
pii: S2589-0042(22)00919-1
pmc: PMC9254453
doi:
Types de publication
Journal Article
Langues
eng
Pagination
104647Informations de copyright
© 2022.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
Curr Opin Allergy Clin Immunol. 2017 Apr;17(2):78-84
pubmed: 28177948
Med Pr. 2016 Dec 22;67(6):833-837
pubmed: 28005090
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9035-40
pubmed: 18577586
Nat Immunol. 2020 Aug;21(8):880-891
pubmed: 32541830
Cell Host Microbe. 2017 May 10;21(5):619-628.e5
pubmed: 28494243
Front Immunol. 2016 Mar 11;7:97
pubmed: 27014276
Toxicol Ind Health. 2010 Sep;26(8):479-86
pubmed: 20529962
Toxicol Appl Pharmacol. 2015 Oct 15;288(2):152-60
pubmed: 26163174
Nature. 2017 May 4;545(7652):98-102
pubmed: 28445461
Eur Respir J. 2006 Nov;28(5):1013-9
pubmed: 16837500
Science. 2008 May 2;320(5876):674-7
pubmed: 18403674
J Occup Health. 2008;50(6):445-54
pubmed: 18931463
Cell. 2016 Oct 6;167(2):382-396.e17
pubmed: 27693356
Nat Immunol. 2008 Aug;9(8):847-56
pubmed: 18604214
Front Immunol. 2017 Feb 13;8:110
pubmed: 28243231
Immunity. 2011 Feb 25;34(2):213-23
pubmed: 21349431
Nat Cell Biol. 2016 Jul;18(7):790-802
pubmed: 27295554
Arch Bronconeumol. 2015 Feb;51(2):86-93
pubmed: 25479706
Chest. 2020 Sep;158(3):1050-1059
pubmed: 32298729
Cell Res. 2011 Jul;21(7):1068-79
pubmed: 21467996
Am J Ind Med. 2019 Mar;62(3):183-191
pubmed: 30658007
Inhal Toxicol. 2020 Aug;32(9-10):375-387
pubmed: 33006295
Lancet. 2012 May 26;379(9830):2008-18
pubmed: 22534002
Immunobiology. 2015 Sep;220(9):1101-6
pubmed: 26024943
J Clin Invest. 2020 Jun 1;130(6):3158-3171
pubmed: 32163377
Biomed Environ Sci. 2012 Oct;25(5):517-25
pubmed: 23122308
Immunity. 2013 Jun 27;38(6):1142-53
pubmed: 23809161
Lancet Respir Med. 2017 May;5(5):445-455
pubmed: 28089118
BMC Public Health. 2015 Dec 18;15:1258
pubmed: 26686997
Am J Ind Med. 2020 Jan;63(1):74-84
pubmed: 31692000
Nature. 2014 May 15;509(7500):366-70
pubmed: 24739961
Nature. 2015 Oct 29;526(7575):666-71
pubmed: 26375259
Nat Commun. 2018 Dec 6;9(1):5226
pubmed: 30523277
Nat Rev Immunol. 2014 Jan;14(1):36-49
pubmed: 24362405
Ecotoxicol Environ Saf. 2020 Oct 1;202:110834
pubmed: 32622305
Science. 2012 Apr 27;336(6080):481-5
pubmed: 22461501
Front Immunol. 2019 Apr 24;10:787
pubmed: 31068929
Sci Adv. 2020 Nov 11;6(46):
pubmed: 33177079
J Clin Invest. 2019 Nov 1;129(11):4691-4707
pubmed: 31566580
Pak J Med Sci. 2022 Jan-Feb;38(1):179-184
pubmed: 35035422
Nat Rev Immunol. 2018 Sep;18(9):545-558
pubmed: 29921905
Chem Soc Rev. 2017 Apr 18;46(8):2091-2126
pubmed: 28230870
Theranostics. 2016 Sep 9;6(12):2052-2067
pubmed: 27698940
Lancet Respir Med. 2019 Apr;7(4):283
pubmed: 30872128
Cell. 2021 Jan 7;184(1):149-168.e17
pubmed: 33278357
Nat Immunol. 2015 Aug;16(8):838-849
pubmed: 26147685
Acta Pharmacol Sin. 2022 Apr;43(4):908-918
pubmed: 34316030