Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection.
SARS-CoV-2
correlate of protection
immunology
inflammation
neutralization
rhesus macaque
vaccines
viruses
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
08 07 2022
08 07 2022
Historique:
received:
09
11
2021
accepted:
22
06
2022
pubmed:
9
7
2022
medline:
16
7
2022
entrez:
8
7
2022
Statut:
epublish
Résumé
The definition of correlates of protection is critical for the development of next-generation SARS-CoV-2 vaccine platforms. Here, we propose a model-based approach for identifying mechanistic correlates of protection based on mathematical modelling of viral dynamics and data mining of immunological markers. The application to three different studies in non-human primates evaluating SARS-CoV-2 vaccines based on CD40-targeting, two-component spike nanoparticle and mRNA 1273 identifies and quantifies two main mechanisms that are a decrease of rate of cell infection and an increase in clearance of infected cells. Inhibition of RBD binding to ACE2 appears to be a robust mechanistic correlate of protection across the three vaccine platforms although not capturing the whole biological vaccine effect. The model shows that RBD/ACE2 binding inhibition represents a strong mechanism of protection which required significant reduction in blocking potency to effectively compromise the control of viral replication.
Identifiants
pubmed: 35801637
doi: 10.7554/eLife.75427
pii: 75427
pmc: PMC9282856
doi:
pii:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Banques de données
Dryad
['10.5061/dryad.1zcrjdfv7']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Alexandre et al.
Déclaration de conflit d'intérêts
MA, RM, MP, SC, NK, SC, TN, BD, MS, MG, ND, MC, PM, MC, CL, AW, SZ, GZ, OS, RS, RL, YL, RT No competing interests declared
Références
Nat Med. 2021 Nov;27(11):2032-2040
pubmed: 34588689
Nature. 2020 Nov;587(7835):619-625
pubmed: 33208946
J Clin Virol. 2020 Sep;130:104572
pubmed: 32769024
J Virol. 2017 Apr 13;91(9):
pubmed: 28202751
PLoS Comput Biol. 2021 Aug 12;17(8):e1009299
pubmed: 34383757
J Virol. 2021 Jan 13;95(3):
pubmed: 33144321
Inhal Toxicol. 2012 Nov;24(13):869-99
pubmed: 23121298
SIAM Rev Soc Ind Appl Math. 2011 Jan 1;53(1):3-39
pubmed: 21785515
Cell Host Microbe. 2021 Jun 9;29(6):917-929.e4
pubmed: 33984285
Clin Infect Dis. 2021 Dec 16;73(12):2332-2334
pubmed: 33639622
Elife. 2021 Sep 27;10:
pubmed: 34569939
J Pharmacokinet Pharmacodyn. 2014 Feb;41(1):15-33
pubmed: 24317870
NPJ Vaccines. 2018 Sep 17;3:36
pubmed: 30245860
N Engl J Med. 2020 Oct 15;383(16):1544-1555
pubmed: 32722908
N Engl J Med. 2021 Jun 24;384(25):2453-2454
pubmed: 33826815
Vaccine. 2020 Feb 24;38(9):2250-2257
pubmed: 31767462
Nat Med. 2020 Sep;26(9):1422-1427
pubmed: 32651581
Nat Commun. 2021 Sep 1;12(1):5215
pubmed: 34471122
Cell Host Microbe. 2021 Apr 14;29(4):522-528.e2
pubmed: 33789085
J R Soc Interface. 2022 Apr;19(189):20210811
pubmed: 35382576
Viruses. 2017 Nov 18;9(11):
pubmed: 29156567
Cell. 2021 Mar 4;184(5):1188-1200.e19
pubmed: 33577765
Nature. 2020 Oct;586(7830):509-515
pubmed: 32967005
J Theor Biol. 2020 Jun 21;495:110254
pubmed: 32205143
PLoS Pathog. 2020 Nov 30;16(11):e1009025
pubmed: 33253297
Lancet Infect Dis. 2021 May;21(5):629-636
pubmed: 33545090
Front Microbiol. 2018 Jul 10;9:1554
pubmed: 30042759
Nat Commun. 2021 Jun 7;12(1):3406
pubmed: 34099652
Clin Infect Dis. 2012 Jun;54(11):1615-7
pubmed: 22437237
Cell Rep Med. 2020 Jul 21;1(4):100059
pubmed: 32835306
J Infect Dis. 2009 Aug 1;200(3):337-46
pubmed: 19569965
Viruses. 2011 Jul;3(7):982-1000
pubmed: 21994766
Nat Med. 2020 May;26(5):676-680
pubmed: 32371934
Elife. 2021 Jul 20;10:
pubmed: 34282728
PLoS Comput Biol. 2021 Mar 17;17(3):e1008785
pubmed: 33730053
Biometrics. 1998 Dec;54(4):1445-62
pubmed: 9883544
Nature. 2021 Feb;590(7847):630-634
pubmed: 33276369
Nat Med. 2021 May;27(5):917-924
pubmed: 33772244
Cell Rep Med. 2021 May 18;2(5):100275
pubmed: 33899033
Cell. 2021 Apr 29;184(9):2348-2361.e6
pubmed: 33730597
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Nat Med. 2021 Jul;27(7):1205-1211
pubmed: 34002089
Nature. 2020 Oct;586(7830):583-588
pubmed: 32731257
Clin Infect Dis. 2013 May;56(10):1458-65
pubmed: 23386629
Fam Med Community Health. 2020 Feb 16;8(1):e000262
pubmed: 32148735
Nat Commun. 2021 Jul 16;12(1):4354
pubmed: 34272374
Proc Natl Acad Sci U S A. 2021 Dec 7;118(49):
pubmed: 34857628
Lancet. 2022 Apr 2;399(10332):1303-1312
pubmed: 35305296
Math Biosci. 2020 Oct;328:108438
pubmed: 32771304
Nat Rev Immunol. 2021 Feb;21(2):83-100
pubmed: 33353987
CPT Pharmacometrics Syst Pharmacol. 2020 Sep;9(9):509-514
pubmed: 32558354
Cell Host Microbe. 2020 Sep 9;28(3):364-370
pubmed: 32798444
Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):
pubmed: 33536313
N Engl J Med. 2021 Jun 3;384(22):2092-2101
pubmed: 33835769
J Infect. 2020 Aug;81(2):318-356
pubmed: 32315724
J Virol. 2007 Jan;81(1):20-9
pubmed: 16928755
Science. 2020 Aug 14;369(6505):806-811
pubmed: 32434945
Science. 2020 Aug 14;369(6505):812-817
pubmed: 32434946
Lancet Reg Health Eur. 2021 Sep;8:100171
pubmed: 34278372
Nature. 2021 Aug;596(7871):268-272
pubmed: 34107529
Nat Rev Immunol. 2021 May;21(5):330-335
pubmed: 33795856
J Virol. 2006 Aug;80(15):7590-9
pubmed: 16840338
Vaccine. 2021 Jul 22;39(32):4423-4428
pubmed: 34210573
Lancet. 2021 Apr 10;397(10282):1351-1362
pubmed: 33798499
PLoS Biol. 2021 Mar 22;19(3):e3001128
pubmed: 33750978
Cell. 2015 Nov 5;163(4):988-98
pubmed: 26544943
J Immunol. 2012 Sep 1;189(5):2645-55
pubmed: 22865916
Vaccines (Basel). 2021 Mar 10;9(3):
pubmed: 33801831
Signal Transduct Target Ther. 2021 Feb 2;6(1):48
pubmed: 33531462
J Clin Invest. 2018 Oct 1;128(10):4387-4396
pubmed: 30148455
Cell Host Microbe. 2021 Jul 14;29(7):1137-1150.e6
pubmed: 34133950
Curr Opin Syst Biol. 2019 Dec;18:27-35
pubmed: 31930181