Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAs.
Corona pandemic
SARS-CoV-2
antiviral compounds
peptide RNA conjugates
siRNA
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
19 09 2022
19 09 2022
Historique:
received:
28
03
2022
pubmed:
9
7
2022
medline:
15
9
2022
entrez:
8
7
2022
Statut:
ppublish
Résumé
The emergence of more transmissible or aggressive variants of SARS-CoV-2 requires the development of antiviral medication that is quickly adjustable to evolving viral escape mutations. Here we report the synthesis of chemically stabilized small interfering RNA (siRNA) against SARS-CoV-2. The siRNA can be further modified with receptor ligands such as peptides using Cu
Identifiants
pubmed: 35802496
doi: 10.1002/anie.202204556
pmc: PMC9350007
doi:
Substances chimiques
Antiviral Agents
0
Ligands
0
RNA, Small Interfering
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202204556Informations de copyright
© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
Références
Genes Dev. 2001 Jan 15;15(2):188-200
pubmed: 11157775
Angew Chem Int Ed Engl. 2022 Sep 19;61(38):e202204556
pubmed: 35802496
Nat Rev Microbiol. 2021 Jul;19(7):409-424
pubmed: 34075212
Lancet Glob Health. 2021 May;9(5):e590-e592
pubmed: 33667404
Nat Rev Microbiol. 2021 Mar;19(3):155-170
pubmed: 33116300
J Am Chem Soc. 2012 Aug 1;134(30):12330-3
pubmed: 22812910
N Engl J Med. 2020 Jun 11;382(24):2289-2301
pubmed: 32521132
Nat Med. 2005 Sep;11(9):944-51
pubmed: 16116432
Nature. 1998 Feb 19;391(6669):806-11
pubmed: 9486653
Front Pharmacol. 2022 Feb 25;13:840639
pubmed: 35281901
Nat Commun. 2021 Jan 28;12(1):668
pubmed: 33510133
Biomed Pharmacother. 2020 Oct;130:110559
pubmed: 32768882
Nat Rev Immunol. 2021 Jun;21(6):382-393
pubmed: 33875867
EMBO J. 2019 Apr 15;38(8):
pubmed: 30872283
Mol Cell. 2007 Jul 6;27(1):91-105
pubmed: 17612493
Nat Med. 2022 Mar;28(3):496-503
pubmed: 35090165
J Clin Pharmacol. 2020 May;60(5):573-585
pubmed: 31777097
In Vitro Cell Dev Biol Anim. 2021 Feb;57(2):104-132
pubmed: 33175307
Chem Biol Drug Des. 2017 Nov;90(5):665-678
pubmed: 28378934
Cell. 2021 Apr 29;184(9):2348-2361.e6
pubmed: 33730597
Angew Chem Int Ed Engl. 2008;47(18):3442-4
pubmed: 18383495
Nature. 2020 Aug;584(7821):443-449
pubmed: 32668443
Nat Rev Drug Discov. 2019 Jun;18(6):421-446
pubmed: 30846871
Adv Drug Deliv Rev. 2012 Dec;64(15):1717-29
pubmed: 22800620
Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9742-7
pubmed: 11481446
Cell Rep. 2020 Jul 21;32(3):107940
pubmed: 32668216
Antiviral Res. 2012 Jun;94(3):288-96
pubmed: 22265858
Nat Commun. 2022 Mar 2;13(1):1128
pubmed: 35236847
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1946-9
pubmed: 25522332
Signal Transduct Target Ther. 2020 Jun 19;5(1):101
pubmed: 32561705