Single vesicle tracking for studying synaptic vesicle dynamics in small central synapses.

Neurons / physiology Presynaptic Terminals / physiology Synapses / physiology Synaptic Transmission / physiology Synaptic Vesicles / physiology
Neurodegenerative disease Single particle tracking Synaptic transmission Synaptic vesicles Vesicle motion Vesicle pool

Journal

Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376

Informations de publication

Date de publication:
10 2022
Historique:
received: 03 02 2022
revised: 20 04 2022
accepted: 27 05 2022
pubmed: 9 7 2022
medline: 21 9 2022
entrez: 8 7 2022
Statut: ppublish

Résumé

Sustained neurotransmission is driven by a continuous supply of synaptic vesicles to the release sites and modulated by synaptic vesicle dynamics. However, synaptic vesicle dynamics in synapses remain elusive because of technical limitations. Recent advances in fluorescence imaging techniques have enabled the tracking of single synaptic vesicles in small central synapses in living neurons. Single vesicle tracking has uncovered a wealth of new information about synaptic vesicle dynamics both within and outside presynaptic terminals, showing that single vesicle tracking is an effective tool for studying synaptic vesicle dynamics. Particularly, single vesicle tracking with high spatiotemporal resolution has revealed the dependence of synaptic vesicle dynamics on the location, stages of recycling, and neuronal activity. This review summarizes the recent findings from single synaptic vesicle tracking in small central synapses and their implications in synaptic transmission and pathogenic mechanisms of neurodegenerative diseases.

Identifiants

DOI: 10.1016/j.conb.2022.102596 PMID: 35803103
pubmed: 35803103
pii: S0959-4388(22)00090-3
doi: 10.1016/j.conb.2022.102596
pii:
doi:

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102596

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest statement Nothing declared.

Auteurs

Chungwon Park (C)

Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077, Hong Kong.

Sangyong Jung (S)

Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 11 Biopolis Way, 138667, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore.

Hyokeun Park (H)

Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077, Hong Kong; Department of Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077, Hong Kong; State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077, Hong Kong. Electronic address: hkpark@ust.hk.

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Classifications MeSH

questionsmedicales.fr › Cellules › Neurones › Single vesicle tracking for studying synaptic...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Terminaisons présynaptiques › Single vesicle tracking for studying synaptic...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Single vesicle tracking for studying synaptic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Single vesicle tracking for studying synaptic...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Vésicules de sécrétion › Vésicules synaptiques › Single vesicle tracking for studying synaptic...