Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence.
Peste des petits ruminants
pathogenesis
virulence
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
08 Jul 2022
08 Jul 2022
Historique:
received:
04
03
2022
accepted:
22
05
2022
entrez:
8
7
2022
pubmed:
9
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Peste des petits ruminants (PPR) is an acute disease of small ruminants caused by a morbillivirus. Clinical observation of the disease in the field revealed that several species of small ruminants are affected to varying degrees. This difference in disease-related effects could depend either on the host or on the virulence of the virus strain. A previous study highlighted the difference in virulence between two strains of PPRV used to infect Saanen goats. For this breed, PPRV Morocco 2008 strain (MA08) was highly virulent while PPRV Côte d'Ivoire 1989 (IC89) strain induced mild disease. Experimental studies generally based on healthy and young animals do not permit exploration of the natural variability of the host susceptibility to PPRV. Therefore, building on the previous study on Saanen goats, the current study focussed on this breed of goat and used commercially available animals with an unknown history of infection with other pathogens. Results confirmed the previous disease pattern for PPRV IC89 and MA08 strains. Viral RNA detection, macroscopic and histological lesions were stronger for the highly virulent MA08 strain. We show here for the first time that viral RNA can be detected in the tissues of vaccinated animals. Viral RNA was also detected for the first time in serum samples, which is in agreement with the role of circulating immune cells in transporting the virus into host target organs. Thus, this study provides insight into the pathogenesis of strains of different virulence of PPRV and will help to better understand the onset of the disease.
Identifiants
pubmed: 35804440
doi: 10.1186/s13567-022-01073-6
pii: 10.1186/s13567-022-01073-6
pmc: PMC9270740
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
57Subventions
Organisme : VetBioNet
ID : 731014
Organisme : European Union Reference Laboratory for Peste des Petits Ruminants (EURL-PPR).
ID : SI2.756606
Informations de copyright
© 2022. The Author(s).
Références
Vet Res. 2014 Feb 22;45:22
pubmed: 24559207
Viruses. 2019 Aug 07;11(8):
pubmed: 31394790
Enferm Infecc Microbiol Clin (Engl Ed). 2018 Apr;36(4):222-224
pubmed: 28238504
J Virol. 2003 Apr;77(7):4181-90
pubmed: 12634376
Rev Elev Med Vet Pays Trop. 1967;20(4):531-6
pubmed: 5626099
Microb Pathog. 2021 Dec;161(Pt A):105232
pubmed: 34627939
Acta Vet Scand. 2017 Sep 7;59(1):56
pubmed: 28882153
Trop Anim Health Prod. 2018 Dec;50(8):1815-1819
pubmed: 29881925
Arch Virol. 2019 Aug;164(8):1997-2003
pubmed: 31089959
J Vet Med B Infect Dis Vet Public Health. 2004 May;51(4):153-9
pubmed: 15228548
Rev Elev Med Vet Pays Trop. 1989;42(3):311-9
pubmed: 2485537
Emerg Infect Dis. 2020 Jan;26(1):51-62
pubmed: 31855146
Transbound Emerg Dis. 2020 Nov;67(6):2881-2891
pubmed: 32502324
Rev Sci Tech. 1990 Dec;9(4):935-81
pubmed: 2132714
Virus Res. 2019 Apr 2;263:173-178
pubmed: 30742853
Adv Virus Res. 2016;95:1-42
pubmed: 27112279
Zoonoses Public Health. 2018 Aug;65(5):584-588
pubmed: 29659194
PLoS One. 2014 Jul 11;9(7):e101226
pubmed: 25013961
Vaccines (Basel). 2020 Apr 06;8(2):
pubmed: 32268574
J Clin Microbiol. 2004 Sep;42(9):4329-31
pubmed: 15365037
Vaccine. 2019 Mar 14;37(12):1667-1673
pubmed: 30772071
Can J Vet Res. 1988 Jan;52(1):46-52
pubmed: 3280108
Science. 2018 Oct 12;362(6411):165-166
pubmed: 30309937
Epidemiol Infect. 2005 Aug;133(4):711-7
pubmed: 16050518
Viruses. 2019 Mar 12;11(3):
pubmed: 30871054
Front Immunol. 2021 Oct 04;12:745315
pubmed: 34671358
PLoS One. 2013;8(2):e55830
pubmed: 23418464
Prev Vet Med. 2007 Jan 16;78(1):85-8
pubmed: 17064800
Rev Elev Med Vet Pays Trop. 1988;41(4):329-35
pubmed: 2855376
BMC Vet Res. 2014 Nov 14;10:263
pubmed: 25394771
J Clin Virol. 2016 Jun;79:6-9
pubmed: 27043968
Microb Pathog. 2018 Apr;117:139-147
pubmed: 29427710
Vet Microbiol. 2014 Aug 6;172(1-2):140-5
pubmed: 24908276
Front Vet Sci. 2020 Feb 28;7:66
pubmed: 32181263
Res Vet Sci. 1995 Jan;58(1):50-5
pubmed: 7709061
PLoS One. 2014 Jan 30;9(1):e87145
pubmed: 24498032
Vet Microbiol. 2012 Nov 9;160(1-2):240-4
pubmed: 22633480
BMC Vet Res. 2019 Dec 16;15(1):452
pubmed: 31842890
Biologicals. 2019 Nov;62:57-64
pubmed: 31588012
Vet Microbiol. 2013 Dec 27;167(3-4):289-95
pubmed: 24100006
J Infect Dev Ctries. 2016 Aug 31;10(8):880-3
pubmed: 27580335
J Biomol Tech. 2006 Jul;17(3):207-17
pubmed: 16870712
Vet J. 2007 Jan;173(1):178-83
pubmed: 16310383
Front Vet Sci. 2021 Feb 19;8:635671
pubmed: 33681333
Vet Microbiol. 1990 Oct;25(1):1-16
pubmed: 2247932