The Potential Tumor-Suppressor DHRS7 Inversely Correlates with EGFR Expression in Prostate Cancer Cells and Tumor Samples.

DHRS7 EGFR STAT3 androgen metabolism phosphorylation prostate cancer survival

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
23 Jun 2022
Historique:
received: 01 06 2022
revised: 20 06 2022
accepted: 21 06 2022
entrez: 9 7 2022
pubmed: 10 7 2022
medline: 10 7 2022
Statut: epublish

Résumé

Prostate cancer (PCa), one of the most common malignancies in men, typically responds to initial treatment, but resistance to therapy often leads to metastases and death. The dehydrogenase/reductase 7 (DHRS7, SDR34C1) is an "orphan" enzyme without known physiological function. DHRS7 was previously found to be decreased in higher-stage PCa, and siRNA-mediated knockdown increased the aggressiveness of LNCaP cells. To further explore the role of DHRS7 in PCa, we analyzed the proteome of LNCaP cells following

Identifiants

pubmed: 35804847
pii: cancers14133074
doi: 10.3390/cancers14133074
pmc: PMC9264982
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Swiss National Science Foundation
ID : 31003A-179400
Pays : Switzerland

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Auteurs

Simon Stücheli (S)

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.

Selene Araya (S)

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.

Caner Ercan (C)

Institute of Medical Genetics and Pathology, University Hospital Basel, 4031 Basel, Switzerland.
Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.

Seraina O Moser (SO)

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.

John Gallon (J)

Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.

Paul Jenö (P)

Proteomics Core Facility, Biozentrum, University of Basel, 4056 Basel, Switzerland.

Salvatore Piscuoglio (S)

Institute of Medical Genetics and Pathology, University Hospital Basel, 4031 Basel, Switzerland.
Visceral Surgery and Precision Medicine Research Laboratory, Department of Biomedicine, University of Basel, 4031 Basel, Switzerland.

Luigi Terracciano (L)

Institute of Medical Genetics and Pathology, University Hospital Basel, 4031 Basel, Switzerland.

Alex Odermatt (A)

Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland.

Classifications MeSH