Transplacental Passage and Fetal Effects of Antineoplastic Treatment during Pregnancy.
cancer
chemotherapy
fetus
newborn
pregnancy
targeted agents
transplacental passage
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Jun 2022
24 Jun 2022
Historique:
received:
23
03
2022
revised:
07
06
2022
accepted:
20
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
10
7
2022
Statut:
epublish
Résumé
The incidence of PAC is relatively infrequent among pregnant women. However, it has gradually increased in recent years, becoming a challenging area for clinicians that should take into account in the same way maternal benefits and fetal potential risks correlated to the antineoplastic treatment. None of the antineoplastic drugs is completely risk-free during the pregnancy, the timing of exposure and transplacental transfer properties influence the toxicity of the fetus. Despite the lack of guidelines about the management of PAC, several studies have described the use and the potential fetal and neonatal adverse events of antineoplastic drugs during pregnancy. We provide a review of the available literature about the transplacental passage and fetal effects of chemotherapy and targeted agents, to guide the clinicians in the most appropriate choices for the management of PAC.
Identifiants
pubmed: 35804875
pii: cancers14133103
doi: 10.3390/cancers14133103
pmc: PMC9264939
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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