The Role of the Fibronectin Synergy Site for Skin Wound Healing.
TGF-β1
catch bond
cell migration
fibronectin
fibrosis
integrin
keratinocyte
myofibroblast
wound healing
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 07 2022
02 07 2022
Historique:
received:
31
05
2022
revised:
25
06
2022
accepted:
30
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Skin is constantly exposed to injuries that are repaired with different outcomes, either regeneration or scarring. Scars result from fibrotic processes modulated by cellular physical forces transmitted by integrins. Fibronectin (FN) is a major component in the provisional matrix assembled to repair skin wounds. FN enables cell adhesion binding of α5β1/αIIbβ3 and αv-class integrins to an RGD-motif. An additional linkage for α5/αIIb is the synergy site located in close proximity to the RGD motif. The mutation to impair the FN synergy region (
Identifiants
pubmed: 35805184
pii: cells11132100
doi: 10.3390/cells11132100
pmc: PMC9265582
pii:
doi:
Substances chimiques
Fibronectins
0
Integrin alpha5beta1
0
Oligopeptides
0
Tgfb1 protein, mouse
0
Transforming Growth Factor beta1
0
arginyl-glycyl-aspartic acid
78VO7F77PN
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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