Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD.

Aged Clonal Hematopoiesis Gene Expression Hematopoiesis / genetics Humans Mutation / genetics Pulmonary Disease, Chronic Obstructive / genetics
COPD clonal hematopoiesis inflammation

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
05 07 2022
Historique:
received: 11 05 2022
revised: 23 06 2022
accepted: 24 06 2022
entrez: 9 7 2022
pubmed: 10 7 2022
medline: 14 7 2022
Statut: epublish

Résumé

Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate potential (CHIP). The association between CHIP and COPD and its relevant effects on DNA methylation in aging are mainly unknown. Analyzing the deep-targeted amplicon sequencing from 125 COPD patients, we found enhanced incidence of CHIP mutations (~20%) with a predominance of DNMT3A CHIP-mediated hypomethylation of Phospholipase D Family Member 5 (

Identifiants

DOI: 10.3390/cells11132121 PMID: 35805204 PMC: PMC9265467
pubmed: 35805204
pii: cells11132121
doi: 10.3390/cells11132121
pmc: PMC9265467
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Stefan Kuhnert (S)

University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus Liebig University, 35392 Giessen, Germany.
ORCID: 0000-0002-1698-2155

Siavash Mansouri (S)

Max Planck Institute for Heart and Lung Research, DZL, CPI, 61231 Bad Nauheim, Germany.

Michael A Rieger (MA)

Department of Medicine, Hematology/Oncology, University Hospital Frankfurt, CPI, Goethe University, 60596 Frankfurt am Main, Germany.
Frankfurt Cancer Institute (FCI), CPI, Goethe University, 60596 Frankfurt am Main, Germany.
ORCID: 0000-0002-4158-5872

Rajkumar Savai (R)

University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus Liebig University, 35392 Giessen, Germany.
Max Planck Institute for Heart and Lung Research, DZL, CPI, 61231 Bad Nauheim, Germany.
Frankfurt Cancer Institute (FCI), CPI, Goethe University, 60596 Frankfurt am Main, Germany.
Institute for Lung Health (ILH), Justus Liebig University, 35392 Giessen, Germany.
ORCID: 0000-0003-1538-2091

Edibe Avci (E)

Max Planck Institute for Heart and Lung Research, DZL, CPI, 61231 Bad Nauheim, Germany.

Gabriela Díaz-Piña (G)

Max Planck Institute for Heart and Lung Research, DZL, CPI, 61231 Bad Nauheim, Germany.
ORCID: 0000-0002-9732-5965

Manju Padmasekar (M)

Max Planck Institute for Heart and Lung Research, DZL, CPI, 61231 Bad Nauheim, Germany.
ORCID: 0000-0001-7060-8319

Mario Looso (M)

Max Planck Institute for Heart and Lung Research, DZL, CPI, 61231 Bad Nauheim, Germany.

Stefan Hadzic (S)

University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus Liebig University, 35392 Giessen, Germany.

Till Acker (T)

Institute for Neuropathology, CPI, Justus Liebig University, 35392 Giessen, Germany.

Stephan Klatt (S)

Institute of Vascular Signalling, Department of Molecular Medicine, CPI, Goethe University, 60596 Frankfurt am Main, Germany.
ORCID: 0000-0003-0064-3367

Jochen Wilhelm (J)

University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus Liebig University, 35392 Giessen, Germany.
Institute for Lung Health (ILH), Justus Liebig University, 35392 Giessen, Germany.
ORCID: 0000-0001-5544-9647

Ingrid Fleming (I)

Institute of Vascular Signalling, Department of Molecular Medicine, CPI, Goethe University, 60596 Frankfurt am Main, Germany.

Natascha Sommer (N)

University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus Liebig University, 35392 Giessen, Germany.

Norbert Weissmann (N)

University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus Liebig University, 35392 Giessen, Germany.
Institute for Lung Health (ILH), Justus Liebig University, 35392 Giessen, Germany.
ORCID: 0000-0003-2675-3871

Claus Vogelmeier (C)

Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, DZL, 35043 Marburg, Germany.

Robert Bals (R)

Department of Internal Medicine V-Pulmonology, Allergology and Critical Care Medicine, Saarland University, 66421 Homburg, Germany.

Andreas Zeiher (A)

Department of Medicine, Cardiology, CPI, Goethe University Hospital, 60596 Frankfurt am Main, Germany.

Stefanie Dimmeler (S)

Institute for Cardiovascular Regeneration, CPI, Goethe University, 60596 Frankfurt am Main, Germany.

Werner Seeger (W)

University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus Liebig University, 35392 Giessen, Germany.
Max Planck Institute for Heart and Lung Research, DZL, CPI, 61231 Bad Nauheim, Germany.
Institute for Lung Health (ILH), Justus Liebig University, 35392 Giessen, Germany.

Soni S Pullamsetti (SS)

University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Cardio-Pulmonary Institute (CPI), Justus Liebig University, 35392 Giessen, Germany.
Max Planck Institute for Heart and Lung Research, DZL, CPI, 61231 Bad Nauheim, Germany.
Institute for Lung Health (ILH), Justus Liebig University, 35392 Giessen, Germany.
ORCID: 0000-0003-0440-8831

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Association of Clonal Hematopoiesis of...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Hématopoïèse clonale › Association of Clonal Hematopoiesis of...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Association of Clonal Hematopoiesis of...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Association of Clonal Hematopoiesis of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of Clonal Hematopoiesis of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Association of Clonal Hematopoiesis of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Broncho-pneumopathie chronique obstructive › Association of Clonal Hematopoiesis of...