Catalytic Antibodies in Bipolar Disorder: Serum IgGs Hydrolyze Myelin Basic Protein.
abzymes
antibodies
bipolar disorder
catalytic IgG
humoral immunity
myelin
myelin basic protein
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
02 Jul 2022
02 Jul 2022
Historique:
received:
19
05
2022
revised:
28
06
2022
accepted:
01
07
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
The pathogenesis of bipolar affective disorder is associated with immunological imbalances, a general pro-inflammatory status, neuroinflammation, and impaired white matter integrity. Myelin basic protein (MBP) is one of the major proteins in the myelin sheath of brain oligodendrocytes. For the first time, we have shown that IgGs isolated from sera of bipolar patients can effectively hydrolyze human myelin basic protein (MBP), unlike other test proteins. Several stringent criteria were applied to assign the studied activity to serum IgG. The level of MBP-hydrolyzing activity of IgG from patients with bipolar disorder was statistically significantly 1.6-folds higher than that of healthy individuals. This article presents a detailed characterization of the catalytic properties of MBP-hydrolyzing antibodies in bipolar disorder, including the substrate specificity, inhibitory analysis, pH dependence of hydrolysis, and kinetic parameters of IgG-dependent MBP hydrolysis, providing the heterogeneity of polyclonal MBP-hydrolyzing IgGs and their difference from canonical proteases. The ability of serum IgG to hydrolyze MBP in bipolar disorder may become an additional link between the processes of myelin damage and inflammation.
Identifiants
pubmed: 35806400
pii: ijms23137397
doi: 10.3390/ijms23137397
pmc: PMC9267049
pii:
doi:
Substances chimiques
Antibodies, Catalytic
0
Immunoglobulin G
0
Myelin Basic Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Science Foundation
ID : 21-75-00071
Références
Science. 1989 Jun 9;244(4909):1158-62
pubmed: 2727702
Neurosci Biobehav Rev. 2019 Mar;98:47-57
pubmed: 30629976
Mult Scler. 1998 Feb;4(1):16-21
pubmed: 9532587
Psychiatry Clin Neurosci. 2014 Jan;68(1):21-36
pubmed: 24102953
J Cell Mol Med. 2010 Mar;14(3):699-709
pubmed: 19438809
Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Dec;5(12):1104-1113
pubmed: 32839153
BMC Psychiatry. 2019 Dec 2;19(1):378
pubmed: 31791284
Arq Neuropsiquiatr. 1990 Dec;48(4):465-8
pubmed: 2094193
J Geriatr Psychiatry Neurol. 2014 Mar;27(1):56-62
pubmed: 24401535
Brain Behav Immun. 1993 Mar;7(1):97-103
pubmed: 7682457
Neuropsychopharmacology. 2014 Sep;39(10):2349-56
pubmed: 24694925
Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(8):61-4
pubmed: 18833110
Biochim Biophys Acta. 2012 Jan;1824(1):68-88
pubmed: 22024571
Amino Acids. 2022 Jan;54(1):99-109
pubmed: 34889995
Psychiatr Clin North Am. 2016 Mar;39(1):125-37
pubmed: 26876323
J Neuropsychiatry Clin Neurosci. 2019 Summer;31(3):246-253
pubmed: 30888921
Mol Psychiatry. 2014 Oct;19(10):1143-9
pubmed: 23999527
Front Pharmacol. 2021 Feb 01;11:594394
pubmed: 33708113
J Affect Disord. 2019 Feb 1;244:60-66
pubmed: 30317016
Ann Palliat Med. 2021 Jan;10(1):350-361
pubmed: 33440965
Lancet Psychiatry. 2022 Feb;9(2):137-150
pubmed: 35026139
Brain Behav Immun. 2017 Oct;65:195-201
pubmed: 28483660
Mol Psychiatry. 2020 Jan;25(1):94-113
pubmed: 31249382
J Biol Chem. 2009 Sep 4;284(36):24622-33
pubmed: 19542217
Mol Psychiatry. 2008 Jun;13(6):558-69
pubmed: 18317468
Transl Psychiatry. 2021 Jun 30;11(1):365
pubmed: 34226491
Cell Mol Life Sci. 2006 Sep;63(17):1945-61
pubmed: 16794783
Curr Neuropharmacol. 2018;16(5):519-532
pubmed: 28847296
Ther Adv Psychopharmacol. 2018 Apr 26;8(9):251-269
pubmed: 30181867
J Psychiatry Neurosci. 2018 Dec 10;44(2):79-88
pubmed: 30525334
Bioessays. 2009 Nov;31(11):1161-71
pubmed: 19795406
Stem Cell Reports. 2021 Apr 13;16(4):825-835
pubmed: 33667413
Autoimmun Rev. 2008 May;7(5):391-7
pubmed: 18486927
Int J Mol Sci. 2020 Sep 30;21(19):
pubmed: 33008051
J Cell Mol Med. 2003 Jul-Sep;7(3):265-76
pubmed: 14594551
Brain Res Bull. 2001 Jul 15;55(5):597-610
pubmed: 11576756
Oxid Med Cell Longev. 2020 Feb 5;2020:8171020
pubmed: 32089782
Biomolecules. 2019 Nov 15;9(11):
pubmed: 31731780
Pharmacol Res. 2021 Jan;163:105325
pubmed: 33278569
Int J Bipolar Disord. 2019 Feb 10;7(1):4
pubmed: 30739250
Methods Mol Biol. 2010;588:33-41
pubmed: 20012816
J Mol Recognit. 2017 Oct;30(10):
pubmed: 28470769
Proc Natl Acad Sci U S A. 1988 Nov;85(21):8206-10
pubmed: 3263647
Proc Soc Exp Biol Med. 1971 Sep;137(4):1328-32
pubmed: 5138458
Microbiol Mol Biol Rev. 1998 Sep;62(3):597-635
pubmed: 9729602
Neurotox Res. 2018 Feb;33(2):316-336
pubmed: 28875469
Int J Bipolar Disord. 2015 Dec;3(1):20
pubmed: 26381439
Psychiatry Res. 2013 Jul 30;208(2):194-6
pubmed: 23246244
Front Immunol. 2017 Apr 21;8:442
pubmed: 28484451
Nat Rev Dis Primers. 2018 Mar 08;4:18008
pubmed: 29516993
Biomolecules. 2021 Aug 02;11(8):
pubmed: 34439806
Pharmacol Biochem Behav. 2019 Feb;177:12-19
pubmed: 30586559
Brain Behav Immun. 2020 Aug;88:870-877
pubmed: 32278851
J Clin Psychiatry. 2017 Sep/Oct;78(8):e986-e993
pubmed: 28922589
Mediators Inflamm. 2018 Dec 30;2018:1218297
pubmed: 30692870
J Mol Recognit. 2019 Feb;32(2):e2759
pubmed: 30112774
J Neuroimmunol. 2012 Nov 15;252(1-2):106-12
pubmed: 22939639
Biofactors. 2019 Mar;45(2):211-222
pubmed: 30496641
J Psychiatr Res. 2021 May;137:401-408
pubmed: 33765452
Trends Mol Med. 2018 Nov;24(11):942-949
pubmed: 30348609
Acta Psychiatr Scand. 2015 Jun;131(6):417-25
pubmed: 25735195
Cell Chem Biol. 2016 Jul 21;23(7):793-804
pubmed: 27427229
J Cell Mol Med. 2004 Jul-Sep;8(3):359-68
pubmed: 15491511
Front Psychiatry. 2020 Feb 26;11:71
pubmed: 32174850
Autoimmun Rev. 2013 Apr;12(6):648-52
pubmed: 23207286
J Affect Disord. 2022 Jan 15;297:208-216
pubmed: 34699854
Psychiatry Investig. 2016 Jan;13(1):18-33
pubmed: 26766943
NPJ Schizophr. 2021 Feb 26;7(1):13
pubmed: 33637732
Neural Plast. 2015;2015:708306
pubmed: 26075104
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:140-5
pubmed: 24447946
J Neuroimmunol. 2015 Oct 15;287:1-8
pubmed: 26439953
Cancer Immunol Res. 2014 May;2(5):381-92
pubmed: 24795350
J Mol Recognit. 2010 Sep-Oct;23(5):495-502
pubmed: 20583146
J Immunol Res. 2020 Aug 10;2020:8986521
pubmed: 32851101
Biochemistry. 1997 Apr 22;36(16):5020-8
pubmed: 9125524
J Mol Recognit. 2011 Nov-Dec;24(6):960-74
pubmed: 22038803